1988
DOI: 10.1111/j.1365-2559.1988.tb02019.x
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The spleen in Hodgkin's disease. An immunohistochemical study of lymphocyte subpopulations and macrophages

Abstract: Lymphocyte subpopulations and macrophages in 16 spleens from patients with Hodgkin's disease were analysed immunohistochemically using monoclonal antibodies of the Leu and the Ki M series. In non-involved splenic tissue there is an increase of T-lymphocytes with an increased T-helper/T-suppressor cell ratio, while Ki M-1, -2, -3 and -5-positive, i.e. phenotypically different macrophages, are reduced. These results indicate that involvement of the spleen in Hodgkin's disease is accompanied by changes with respe… Show more

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