The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast <i>Schizosaccharomyces pombe</i>

Hagan, Iain

doi:10.1042/bst0361097

Cited by 24 publications

(21 citation statements)

References 51 publications

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“…These regulations are exerted by the major protein kinases Plo1, Pom1, and Cdr2. Importantly, these kinases also regulate the proper timing of cell division, effectively coupling temporal and spatial aspects of cell division: as discussed above, in addition to division plane positioning, Pom1 and Cdr2 also participate in the sensing of cell length to trigger cell division at the proper cell size; in the case of Plo1, not only does it control the position of the contractile ring through Mid1 and its assembly and contraction through the SIN but it is also a key player of the amplification loops leading to Cdc2 activation [see Hagan, 2008 for a review].…”

Section: Discussionmentioning

confidence: 99%

“…773 n above, in addition to division plane positioning, Pom1 and Cdr2 also participate in the sensing of cell length to trigger cell division at the proper cell size; in the case of Plo1, not only does it control the position of the contractile ring through Mid1 and its assembly and contraction through the SIN but it is also a key player of the amplification loops leading to Cdc2 activation [see Hagan, 2008 for a review].…”

Section: Spatial Regulation Of Cytokinesis In Fission Yeastmentioning

confidence: 99%

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Mid1/anillin and the spatial regulation of cytokinesis in fission yeast

Rincón

Paoletti

2012

Cytoskeleton

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Cell division is a critical and irreversible step in the cell cycle. The strategies that cells follow to regulate the position of the division plane must take into account the global geometry of the cell as well as position of the genetic material to ensure its accurate segregation into daughter cells of a given cell shape and size. Along the years, research on Schizosaccharomyces pombe, a wellrecognized model organism for cell division studies has allowed a detailed molecular understanding of the spatial mechanisms regulating cytokinesis. Division plane position in this unicellular rod-shaped organism, which divides by the assembly and constriction of a medially placed actomyosin ring, largely depends on the anillinlike protein Mid1. Therefore, the major pathways controlling the position of the division plane converge on Mid1. In this review, we make an overview of the studies that have deciphered how Mid1 localization and scaffolding activities are controlled over the cell cycle to ensure the symmetrical division of fission yeast cells. These studies have revealed new mechanisms generating spatial information based on nuclear shuttling of the division plane factor Mid1 and on the establishment of cortical inhibitory gradients of the cell polarity kinase Pom1. V C 2012 Wiley Periodicals, Inc Key Words: cytokinesis, fission yeast, contractile ring, Mid1, cell division Introduction C ytokinesis is the final step of cell division that physically separates the daughter cells at the end of the cell cycle. It is a universal process, essential for cell proliferation, for the survival of unicellular organisms or for the development of multicellular organisms, whose major features have been well conserved along evolution. As an irreversible event, cytokinesis is under tight spatial and temporal regulation. Defective cytokinesis can indeed alter cell geometry or size, perturb cellular organization within tissues or prevent the accurate transmission of the genetic material, producing aneuploid cells, which can affect the survival of unicellular species or favor cancer and tumor progression in animal species.Cytokinesis is first strictly coordinated with mitotic progression in order to successfully fulfill chromosome segregation. Checkpoint mechanisms monitoring the function of the mitotic apparatus can halt cells in metaphase, which prevents cytokinesis until actual chromosome segregation in anaphase.Second, spatial regulatory pathways define the position of the division plane according to the position of the nucleus at mitotic entry, or of the mitotic apparatus, perpendicular to the axis of chromosome segregation. This ensures the efficient segregation of the genetic material and allows to control the geometry of the daughter cells in response to morphogenetic programs. Cell division can indeed be symmetric or asymmetric to allow the generation of daughter cells of different sizes. Orientation of the division plane is also modulated to properly position the daughter cells inside embryos or tissues and to permit the asymm...

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Section: Discussionmentioning

confidence: 99%

Section: Spatial Regulation Of Cytokinesis In Fission Yeastmentioning

confidence: 99%

Mid1/anillin and the spatial regulation of cytokinesis in fission yeast

Rincón

Paoletti

2012

Cytoskeleton

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“…During late G2, NIMA kinase, Fin1, blocks the recruitment of the protein phosphatase 1 to the SPB, which then allows the recruitment of Plo1 to Cut12 and the SPB [123]. Increased Plo1 activation at the SPB is thought to further activate cyclin B/Cdk1 by enhancing Cdc25 (Cdk1 activator) and inhibiting Wee1 (Cdk1 inhibitor) activities [124]. Importantly, regulation of mitotic entry by the centrosome has also been rstb.royalsocietypublishing.org Phil.…”

Section: (B) Consequences Of Centrosome Amplification In Interphase (mentioning

confidence: 99%

Causes and consequences of centrosome abnormalities in cancer

Godinho

Pellman

2014

Phil. Trans. R. Soc. B

304

336

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Centrosome amplification is a hallmark of cancer. However, despite significant progress in recent years, we are still far from understanding how centrosome amplification affects tumorigenesis. Boveri's hypothesis formulated more than 100 years ago was that aneuploidy induced by centrosome amplification promoted tumorigenesis. Although the hypothesis remains appealing 100 years later, it is also clear that the role of centrosome amplification in cancer is more complex than initially thought. Here, we review how centrosome abnormalities are generated in cancer and the mechanisms cells employ to adapt to centrosome amplification, in particular centrosome clustering. We discuss the different mechanisms by which centrosome amplification could contribute to tumour progression and the new advances in the development of therapies that target cells with extra centrosomes.

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“…The spindle pole body (SPB) serves as a microtubule-organising centre, and coordination point for cell cycle regulators (Grallert et al, 2012;Grallert et al, 2013;Hagan, 2008). Association of SIN proteins to the SPB plays an important part in the regulation of the SIN (reviewed by Johnson et al, 2012;Simanis, 2003).…”

Section: Introductionmentioning

confidence: 99%

Analysis ofS. pombeSIN protein SPB-association reveals two genetically separable states of the SIN

Wachowicz

Chasapi

Krapp

et al. 2014

Journal of Cell Science

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The Schizosaccharomyces pombe septation initiation network (SIN) regulates cytokinesis, and asymmetric association of SIN proteins with the mitotic spindle pole bodies (SPBs) is important for its regulation. Here, we have used semi-automated image analysis to study SIN proteins in large numbers of wild-type and mutant cells. Our principal conclusions are: first, that the association of Cdc7p with the SPBs in early mitosis is frequently asymmetric, with a bias in favour of the new SPB; second, that the early association of Cdc7p-GFP to the SPB depends on Plo1p but not Spg1p, and is unaffected by mutations that influence its asymmetry in anaphase; third, that Cdc7p asymmetry in anaphase B is delayed by Pom1p and by activation of the spindle assembly checkpoint, and is promoted by Rad24p; and fourth, that the length of the spindle, expressed as a fraction of the length of the cell, at which Cdc7p becomes asymmetric is similar in cells dividing at different sizes. These data reveal that multiple regulatory mechanisms control the SIN in mitosis and lead us to propose a two-state model to describe the SIN.

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The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe

Cited by 24 publications

References 51 publications

Mid1/anillin and the spatial regulation of cytokinesis in fission yeast

Mid1/anillin and the spatial regulation of cytokinesis in fission yeast

Causes and consequences of centrosome abnormalities in cancer

Analysis ofS. pombeSIN protein SPB-association reveals two genetically separable states of the SIN

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