The Spinal Monoaminergic Systems Relating to Ejaculation Ejaculation and Monoamines After Spinal Cord Transection

Abstract

The authors investigated the relationship between ejaculation and spinal monoamine levels by transecting the dog spinal cord at the various levels. From the results obtained in this study it was concluded that the lumbar and upper sacral segments of the spinal cord are important for ejaculation, and that the suppression of ejaculation by lower lumbar to upper sacral transection may be induced by increase in serotonin in the 5th lumbar -1st sacral segments. Ejakulation und Monoarninkonzentration nach Durchtrennung der RuckenrnarksbahnenZusammenfassung: Die Autoren untersuchten Zusammenhange zwischen Ejakulation und spinalen Monoaminkonzentrationen nach Durchtrennung der Riickenmarksbahnen in verschiedenen Segmenten beim Hund. Aus den Ergebnissen dieser Studie ist zu schlieaen, dai3 die Segmente des Lumbal-und oberen Sacralmarks fur die Ejakulation von Bedeutung sind, und dai3 die Unterdriickung der Ejakulation nach Durchtrennen des unteren Lumbalbis zum oberen Sacralmark induziert sein konnte durch einen Anstieg des Serotonins im 5. Lumbal-und 1. Sacralsegment.

Effects of the dopamine D3 receptor agonist 7-hydroxy-2-(di-N -propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model

“…Penile erection and ejaculation have been induced by PCA via serotonin release from the lower spinal cord in anesthetised rats (Humphries et al., ; Yonezawa et al., ). Descending serotonergic fibre activity in the spinal cord also affects sexual response after the direct infusion of dopamine into the spinal cord (Kimura et al., ; Miyamoto, Yonezawa, Tadano, Kisara, & Kimura, ). The administration of dopamine has been shown to stimulate emission from the seminal vesicles; however, penile reflexes were barely affected (Pehek, Thompson, & Hull, ; Stefanick, Smith, Clark, & Davidson, ).…”