“…Thanks to the recent biological breakthrough to gain a full understanding of AKI, many more researchers have concentrated on clarifying the mechanisms underneath the AKI therapy, and by applying biomolecules like siRNAs for the inhibition of specific pathways, more novel biological signals were revealed. 56–62 Advanced strategies with more precise targets have been developed for effective disease management, which might be the future direction for the related designs. In the meantime, the effective delivery of those molecules has become a new demand and challenge.…”