The Spectrum of Spitz Nevi

Ferrara, Gerardo; Argenziano, Giuseppe; Soyer, H. Peter; Chimenti, Sergio; Blasi, Arturo Di; Pellacani, Giovanni; Peris, Ketty; Piccolo, Domenico; Rubegni, Pietro; Seidenari, Stefania; Staibano, Stefania; Zalaudek, Iris; Rosa, Gaetano De

doi:10.1001/archderm.141.11.1381

Cited by 147 publications

(56 citation statements)

References 37 publications

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“…However, this staining is nonspecific because these elements are stained with the same tone and intensity. The identification of ECM protein acquires an important role in these cases where its fibrillar elements are altered (Murali et al 2009;Ferrara et al 2005;Provenzano et al 2006). In some cases, it is necessary to evaluate the ECM integrity to establish the diagnosis of an invasion in a variety of neoplasms (Leber and Efferth 2009;Provenzano et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…In the blue nevi, Spitz nevi, and related lesions, the degree of dermal sclerosis (the characteristics of collagen bands, the neoplastic cell organization, and pigmentation degree) should be evaluated for establishing the diagnosis (Murali et al 2009;Ferrara et al 2005). In these lesions, numerous techniques are currently used and evaluated in parallel.…”

Section: Discussionmentioning

confidence: 99%

“…There are cases of difficult diagnosis because of the undifferentiation of neoplastic cells, poor pigmentation, and sometimes the presence of other pigments. In the study of this type of lesion, the characteristics of collagen bands, neoplastic cell organization, and the pigmentation degree should be evaluated for establishing the diagnosis (Murali et al 2009;Ferrara et al 2005). Different techniques should be used and interpreted in parallel, and a correlation of these findings must be further performed.…”

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confidence: 99%

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A Novel Histochemical Method for a Simultaneous Staining of Melanin and Collagen Fibers

Carriel

Aneiros‐Fernández

Arias‐Santiago

et al. 2011

J Histochem Cytochem.

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SummaryFor the histopathologic diagnosis of melanocytic lesions, it could be necessary to identify the melanin pigment because its visualization is unspecific with hematoxylin-eosin (HE). The Fontana-Masson (FM) technique is used in histopathology in this type of lesion, which allows the identification of the pigment, but it loses all the morphologic parameters. The authors describe a modification to the FM method, for the evaluation of the morphology, the argentaffin reaction of the melanin, and collagens fibers of the extracellular matrix simultaneously, for which they have developed the Fontana-Masson picrosirius (FMPS) method. Biopsies of different melanocytic lesions were used for the performance of the HE, FM, and FMPS methods. The pixel intensity of the reaction for melanin, collagen, and epithelium was determined with ImageJ software. The FMPS method allows the evaluation of morphological characteristics, identifying the melanin pigment and collagen fibers with high intensity simultaneously. This method does not differ significantly from FM in the identification of melanin, maintaining its sensitivity and specificity. In addition, it does not differ in the demonstration of the morphology with HE. However, FMPS is significantly superior in the identification of collagen fibers. The FMPS method combines morphological and histochemical parameters that could be useful in the study of pigmented lesions of melanocytic origin. (J Histochem Cytochem 59:270-277, 2011)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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A Novel Histochemical Method for a Simultaneous Staining of Melanin and Collagen Fibers

Carriel

Aneiros‐Fernández

Arias‐Santiago

et al. 2011

J Histochem Cytochem.

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“…Dermoscopy enables us today to make a confident diagnosis of SNi [10]. These nevi are observed both at pediatric and adult age.…”

Section: Discussionmentioning

confidence: 99%

Spitz Nevus: Follow-Up Study of 8 Cases of Childhood Starburst Type and Proposal for Management

Nino¹,

Brunetti²,

Delfino³

et al. 2008

Dermatology

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Spitz nevus is an uncommon, benign melanocytic neoplasm that shares many clinical and histological features with melanoma. It presents clinical ambiguity that makes the diagnosis and management of the patient difficult. We present our experience in the management of Spitz nevus by rigorous dermoscopic long-term follow-up of 8 Spitz nevi in patients younger than 12 years. Dermoscopic images, acquired every 6 months, show evolution and modifications of these lesions. The aim of this paper is to better understand the long-term modifications of nevi with starburst pattern to avoid surgical excision of these lesions in the pediatric age group.

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“…The increasing use of dermoscopy (dermatoscopy, skin surface microscopy) in the preoperative evaluation of cutaneous lesions is going to dramatically change our view on spitzoid neoplasms [1,2]. Before dermoscopy, Spitz nevus (SN) could be mainly identified by clinicians as a pink to red papulonodular lesion of the face and the extremities of children.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Atypical Spitzoid Neoplasms: A Review with Emphasis on ‘Red’ (‘Spitz’) Tumors and ‘Blue’ (‘Blitz’) Tumors

et al. 2010

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Background: The diagnosis of pediatric atypical Spitz nevus/tumors (pASNT) is an emerging challenge in clinical dermatology and dermatopathology. Objective and Methods: We review the main clinicopathologic issues raised by pASNT and describe 2 examples of different clinicopathologic subsets of lesions. Results: While Spitz/Reed nevi are commonly small- to medium-sized, tan to black plaques, pASNT are large and nodular, either ‘red’ (dotted and/or polymorphous vascular pattern on dermoscopy; spindle and/or epithelioid tumors on histopathology: Spitz tumors, sensu strictiori) or ‘blue’ (homogeneous blue color on dermoscopy; intimate admixture of epithelioid cells and heavily pigmented dendritic cells on histopathology: Blitz tumors or pigmented epithelioid melanocytomas). Conclusions: Different clinicopathologic settings of pASNT probably exist. Dermoscopy can aid in their recognition and classification.

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The Spectrum of Spitz Nevi

Cited by 147 publications

References 37 publications

A Novel Histochemical Method for a Simultaneous Staining of Melanin and Collagen Fibers

A Novel Histochemical Method for a Simultaneous Staining of Melanin and Collagen Fibers

Spitz Nevus: Follow-Up Study of 8 Cases of Childhood Starburst Type and Proposal for Management

Pediatric Atypical Spitzoid Neoplasms: A Review with Emphasis on ‘Red’ (‘Spitz’) Tumors and ‘Blue’ (‘Blitz’) Tumors

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