2024
DOI: 10.1152/physiol.00026.2024
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The Spectrum of Renal “TFEopathies”: Flipping the mTOR Switch in Renal Tumorigenesis

Nicola Alesi,
Kaushal Asrani,
Tamara L. Lotan
et al.

Abstract: The Mammalian Target of Rapamycin Complex 1 (mTORC1) is a serine threonine kinase that couples nutrient and growth factor signaling to the cellular control of metabolism and plays a fundamental role in aberrant proliferation in cancer. mTORC1 has previously been considered an "on/off" switch, capable of phosphorylating the entire pool of its substrates when activated. However recent studies have indicated that mTORC1 may be active towards its canonical substrates, 4EBP1 and S6K, involved in mRNA translation an… Show more

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