The spectrum of progressive multifocal leukoencephalopathy: a practical approach

Bartsch, Thorsten; Rempe, Torge; Leypoldt, Frank; Riedel, Christian; Jansen, Olav; Berg, Daniela; Deuschl, Günther

doi:10.1111/ene.13906

Cited by 48 publications

(49 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of our patients were tested in-house using the Euroimmune commercial biochip immunofluorescence cell-based assay. Although there is a possibility of false-positive results in some of the cases, the risk is low as the Euroimmune cell-based assay has an 82.1% positive predictive value (18,19).…”

Section: Discussionmentioning

confidence: 99%

Case Series: Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Related Disease Spectrum

et al. 2020

View full text Add to dashboard Cite

Introduction:Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-related disease was initially described as a subtype of neuromyelitis optica spectrum disorder (NMOSD) with antibodies against MOG. However, it has recently been described as a separate disease entity with clinical and radiological features that overlap those of multiple sclerosis (MS) and NMOSD; the clinical features of this disease phenotype remain undetermined. We herein report the clinical presentation of nine MOG-IgG-positive patients, not all of whom fulfill the NMOSD criteria, in order to highlight the features and challenges of this condition. Method:We retrospectively reviewed the records of the London (Ontario) MS clinic to identify patients diagnosed with positive MOG antibodies based on the 2015 NMOSD consensus criteria.Result: Nine patients were identified, all Caucasian. Seven (78%) were female, and the median age of onset was 41 years (range, 28-69 years); the median Expanded Disability Status Scale score at onset was 3.0 (range, 2.0-4.0). A monophasic course was noted in two (22.2%) patients, while the median number of relapse events was 3 (range 2-5) in 77.8% of the patients. Optic neuritis and transverse myelitis contributed equally as initial manifestations in three individuals (33%), while brainstem relapse was reported in two individuals (22%). The brain magnetic resonance imaging findings were compatible with McDonald's 2010 dissemination in space criteria in three cases (33%). Short myelitis and an (H)-sign were each documented in one patient. Conclusion:The phenotypes of MOG Ab-positive cases exhibited overlapping features with MS and NMOSD. This finding highlights the importance of screening for anti-MOG in individuals with demyelinating symptoms, in consideration of the possibility of false-positive MOG Ab results.

show abstract

Section: Discussionmentioning

confidence: 99%

Case Series: Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Related Disease Spectrum

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Immunotherapy might be another potential trigger. Treatment with immunotherapy has been linked to progressive multifocal leukoencephalopathy (PML) caused by John Cunningham virus . Expert opinion from neurology and radiology suggest that the patient's case lacked the clinical and radiological hallmarks for PML .…”

Section: Discussionmentioning

confidence: 99%

Mania as a possible complication of immunotherapy

Mavrotas

Murray

2020

Prog Neurol Psychiatry

View full text Add to dashboard Cite

show abstract

“…We read with interest the article 'The spectrum of progressive multifocal leukoencephalopathy: a practical approach' by Bartsch et al [1]; the authors also mentioned individuals affected by sarcoidosis among the patient groups where increased vigilance for progressive multifocal leukoencephalopathy (PML) is needed. Indeed, in this regard, here we report on a sarcoidosis patient who developed PML presenting with an isolated pseudobulbar palsy.…”

Section: Dear Editormentioning

confidence: 99%