The Spectrum of Pharmacological Actions of Syringetin and Its Natural Derivatives—A Summary Review

Abstract

Mono- and poly-O-methylated flavonols and their glycoside derivatives belong to the group of natural plant polyphenols with a wide spectrum of pharmacological activities. These compounds are known for their antioxidant, antimutagenic, hepatoprotective, antidiabetic, and antilipogenic properties. Additionally, they inhibit carcinogenesis and cancer development. Having in mind the multidirectional biological activity of methylated flavonols, we would like to support further study on their health-promoting activities; in this review we summarized the most recent reports on syringetin and some of its structural analogues: laricitrin, ayanin, and isorhamnetin. Natural sources and biological potential of these substances were described based on the latest research papers.

Antimicrobial Potential of Different Isolates of Chaetomium globosum Combined with Liquid Chromatography Tandem Mass Spectrometry Chemical Profiling

“…It is also able to inhibit the growth of cancer cells via the induction of cell cycle arrest in the G2/M phase and the initiation of apoptosis. Syringetin can inhibit the alpha-glucosidase enzyme, so it can reduce postprandial glycemia [122].…”

Siringaldehit Bazlı Yeni 2,4,6-Triarilpiridin Türevlerinin Antioksidan Aktiviteleri ve Teorik Profili

“…Syringaldehyde, a naturally occurring compound found in a wide range of plants, has been extensively studied for its diverse biological activities. Its derivatives have been shown to possess various beneficial properties, including anti-inflammatory, anticancer, and potent antioxidant activities [11][12][13]. As a result, the search for antioxidant compounds has expanded to various fields of research, including nutrition, pharmacology, and biotechnology.…”

Phytochemical Analysis, Acetylcholinesterase Inhibition, Antidiabetic and Antioxidant Activities of Atriplex halimus L. (Amaranthaceae Juss.)

“…As well as cardiovascular disease, it is also used in the treatment of anemia trouble and rheumatism. [10] Recent studies reported antioxidant, [15][16][17][18] Antiinflammatory, [19] Antimicrobial [20,21] , hypoglycemic, [22,23] Hepatoprotective, [24] anti-Alzheimer, [25,26] antidiabetic [9,27] and Wound healing [15] properties of plant extracts and phytochemicals from Mediterranean saltbush.…”