The Spectrum of Lincomycin-Clindamycin Colitis

Viteri, Alfredo L.; Howard, Paxton H.; Dyck, Walter P.

doi:10.1016/s0016-5085(74)80005-3

Cited by 38 publications

(9 citation statements)

References 6 publications

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“…During the same period no case of colitis secondary to clindamycin therapy has been seen in the University Department of Surgery at Leeds. The experience of investigators in the United States (Benner and Tellman, 1970;Pittman et al, 1974;Viteri et al, 1974) and New Zealand (Scott et al, 1973) who have reported this complication has been commented on by Geddes (1974), who suggested a possible geographical difference in the occurrence of side-effects. The choice of these antibiotics has been supported by the 100 per cent sensitivity of thestaphylococcus and the resistance of only one proteus and one coliform organism isolated.…”

Section: Discussionmentioning

confidence: 98%

The treatment of acute abscesses by incision, curettage and primary suture under antibiotic cover

Jones

Wilson

1976

British Journal of Surgery

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One hundred and fifty consecutive acute abscesses have been treated by incision, curettage and primary suture under antibiotic cover. The antibiotic used in this series was lincomycin 600 mg i.m. with premedication and clindamycin 150 mg 6-hourly for 4 days postoperatively (children and infants received smaller doses). Similar results for the rate of healing were achieved in all groups of abscesses. A case is made for the use of the technique of incision, currettage and primary suture with antibiotic covere for acute abscesses as an alternative to conventional methods of treatment.

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Section: Discussionmentioning

confidence: 98%

The treatment of acute abscesses by incision, curettage and primary suture under antibiotic cover

Jones

Wilson

1976

British Journal of Surgery

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“…There has been recent concern with the use of lincomycin and clindamycin because of occasional reports of lifethreatening pseudomembranous colitis (Scott et al, 1973;Viteri et al, 1974). The pathogenesis of this complication is unknown; it appears to be independent of the route of administration of the antibiotic (Leading Article, 1974), and tends to occur in patients with severe coexisting disease.…”

Section: Discussionmentioning

confidence: 99%

Prophylaxis against anaerobic sepsis in bowel surgery

Keighley

Crapp

Burdon

et al. 1976

British Journal of Surgery

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Sixty-two patients were admitted to a prospective randomized controlled trial to investigate the influence of a prophylactic antibiotic, lincomycin, on anaerobic sepsis following bowel surgery. The incidence of postoperative sepsis was reduced from 45 to 18 per cent (P less than 0-025). Wound infections were reduced from 38 to 12 percent (P less than 0-05). Intra-abdominal or pelvic abscess occurred in 1 of the treated group compared with 3 controls. Septicaemia occurred after operation in 1 patient receiving lincomycin and in 3 of the controls; in 2 of the latter, pure growths of bacteroides were isolated from the blood cultures and 1 of these patients died. Although lincomycin had no influence on the number of patients who developed aerobic postoperative infections, there was a significant reduction in the incidence of sepsis due to bacteroides, which occurred in 10 of the control group compared with 1 in the lincomycin group (P less than 0-005). No patients developed complications attributable to lincomycin, such as pseudomembranous colitis. These data indicate that the genus Bacteroides are important pathogenic organisms and are responsible for postoperative morbidity. Furthermore, anaerobic sepsis can be reduced by appropriate prophylactic antibiotics.

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“…The reported incidence of pseudomembranous colitis has varied from i in 118,000 to 10% of 200 patients, 5% being the mean (Benner & Tellman, 1970;Viteri, Howard & Dyck, 1974;Tedesco et al, 1974;McCleod, 1975). Pseudomembranous colitis usually occiurs in patients with serious underlying diseases such as subacute bacterial endocarditis (Scott et al, 1973) and many patients have had other antibiotics such as ampicillin and tetracycline which may cause pseudomembranous colitis (Finland, Grigsby & Haight, 1954;Schapiro & Newman, 1973).…”

Section: Resultsmentioning

confidence: 99%