The spectrum of leukomalacia using cranial ultrasound

Vries, Linda S. de; Eken, P.; Dubowitz, Lilly

doi:10.1016/s0166-4328(05)80189-5

Cited by 815 publications

(519 citation statements)

References 28 publications

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“…The automated brainstem response used in this study is considered the standard for the assessment of infants. 38 However, subtle auditory abnormalities might have been missed. The periventricular site of involvement of the lesions discussed in this study may be more likely to affect the pathways of the optic radiations rather than the temporal lobe areas involved in audition.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Differential Diagnosis and Neurodevelopmental Outcome of Cerebral White Matter Lesions in Premature Infants

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Ultrasonographic Differential Diagnosis and Neurodevelopmental Outcome of Cerebral White Matter Lesions in Premature Infants

et al. 1999

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“…The following neonatal data were recorded: gender, gestational age at birth in completed weeks, birthweight, neonatal death and severe neonatal morbidity (defined as any of the following: respiratory distress syndrome, necrotising enterocolitis ≥stage II, 15 neonatal sepsis, renal failure or severe cerebral injury). Severe cerebral injury was defined as the presence of at least one of the following findings on cranial imaging: intraventricular haemorrhage ≥grade III, 16 periventricular leucomalacia ≥grade II, 17 (progressive and non-progressive) ventricular dilation ≥97th percentile, 18 arterial or venous infarct or other cerebral anomalies associated with adverse neurological outcome. Socio-economic status of the parents was registered as high, average or low according to the Dutch Sociaal Cultureel Planbureau.…”

Section: Methodsmentioning

confidence: 99%

Long‐term neurodevelopmental outcome after selective feticide in monochorionic pregnancies

Klink

Koopman

Middeldorp

et al. 2015

BJOG

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ObjectiveTo assess the incidence of and risk factors for adverse long‐term neurodevelopmental outcome in complicated monochorionic pregnancies treated with selective feticide at our centre between 2000 and 2011.DesignObservational cohort study.SettingNational referral centre for fetal therapy (Leiden University Medical Centre, the Netherlands).PopulationNeurodevelopmental outcome was assessed in 74 long‐term survivors.MethodsChildren, at least 2 years of age, underwent an assessment of neurologic, motor and cognitive development using standardised psychometric tests and the parents completed a behavioural questionnaire.Main outcome measuresA composite outcome termed neurodevelopmental impairment including cerebral palsy (GMFCS II‐V), cognitive and/or motor test score of <70, bilateral blindness or bilateral deafness requiring amplification.ResultsA total of 131 monochorionic pregnancies were treated with selective feticide at the Leiden University Medical Centre. Overall survival rate was 88/131 (67%). Long‐term outcome was assessed in 74/88 (84%). Neurodevelopmental impairment was detected in 5/74 [6.8%, 95% confidence interval (CI), 1.1–12.5] of survivors. Overall adverse outcome, including perinatal mortality or neurodevelopmental impairment was 48/131 (36.6%). In multivariate analysis, parental educational level was associated with cognitive test scores (regression coefficient B 3.9, 95% CI 1.8–6.0). Behavioural problems were reported in 10/69 (14.5%).ConclusionsAdverse long‐term outcome in survivor twins of complicated monochorionic pregnancies treated with selective feticide appears to be more prevalent than in the general population. Cognitive test scores were associated with parental educational level.Tweetable abstractNeurodevelopmental impairment after selective feticide was detected in 5/74 (6.8%, 95% CI 1.1–12.5) of survivors.

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“…IVH was graded at cerebral ultrasound according to Papile et al 9 c-PVL was defined by cranial ultrasound as an area of increased echogenicity of the periventricular white matter in acute phase, which subsequently evolved into cystic lesion. 10 Cranial ultrasounds were routinely performed during the infant hospital stay by experienced examiners (neonatologists or radiologists) according to the following protocol: day 1, 3, 7, 10, 15 and then at least every 2 weeks or more often as clinically indicated, until discharge.…”

Section: Methodsmentioning

confidence: 99%

Hypoproteinemia on the first day of life and adverse outcome in very preterm infants admitted to the neonatal intensive care unit

et al. 2011

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Objective: We aimed to investigate the relationship between day-1 hypoproteinemia and severe adverse outcome (SAO) in very preterm infants admitted to the neonatal intensive care unit (NICU).Study Design: Retrospective study of all patients born from 24 to 31 weeks gestation and cared for in our NICU over an 8-year period. Infants were excluded if the serum protein value on the first day of life was not available.Result: A total of 913 patients were included. In all, 14.6% presented with SAO (death or severe neurological injury on cranial ultrasound). Hypoproteinemia (total protein level <40 g l À1 ) on day 1 of life occurred in 19.5 % of all patients. The rate of SAO was 33.7% in patients with hypoproteinemia and 9.9% in those with normoproteinemia (P<0.0001). Logistic and multiple regression analysis confirmed that the association hypoproteinemia-SAO remained significant after adjustment for the other major predictors of outcome present at baseline (odds ratio 3.4; 95% confidence interval 2.1-5.4; P<0.0001).Conclusion: Hypoproteinemia was highly associated with SAO in this cohort of critically ill preterm infants. We are unable to explain the link between hypoproteinemia and adverse outcome in our population. This investigation serves as a hypothesis-generating report of a large preterm infants sample, and suggests the need to assess the predictive accuracy for adverse outcome of hypoproteinemia in future prospective studies.

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The spectrum of leukomalacia using cranial ultrasound

Cited by 815 publications

References 28 publications

Ultrasonographic Differential Diagnosis and Neurodevelopmental Outcome of Cerebral White Matter Lesions in Premature Infants

Ultrasonographic Differential Diagnosis and Neurodevelopmental Outcome of Cerebral White Matter Lesions in Premature Infants

Long‐term neurodevelopmental outcome after selective feticide in monochorionic pregnancies

Hypoproteinemia on the first day of life and adverse outcome in very preterm infants admitted to the neonatal intensive care unit

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