The Spectrum of Genodermatosis in Muslim Majority Population of North India

Abstract

Introduction: Genetic diseases of the skin or genodermatoses are a group of inherited disorders with a conglomeration of cutaneous and systemic signs and symptoms. Study aimed to document the pattern, describe the diverse clinical presentations and define the magnitude of various genetic dermatological disorders among the patients from Muslim majority population of north India. Material and Methods: One hundred and twenty eight patients with the clinically proven genetic dermatological disorder reporting to a tertiary care teaching hospital during a period one and a half year from August 2014 to January 2016 were enrolled and epidemiologic and demographic features studied in detail. Results: Among 128 patients, there were 69 males and 59 females with M: F ratio of 1.17:1. Prevalence of genetic disorders was 0.72 per 100 new cases. The most common group of disorder reported was ichthyosiform disorder in 30 patients followed by genetic blistering disorders (epidermolysis bullosa) in 13. Family history of same disorder was seen in 43/128(33.59%). Parental history of consanguinity was observed in 74/128 (57.8%). Conclusions: This study is first of its kind from this part of country to document the pattern of genetic dermatological disorders in Muslim majority population. We found a high rate of parental consanguinity, a high percentage of patients with a positive family history, and many siblings affected by these genetic skin diseases.