The Spectrum of Gastrointestinal Manifestations in Lyme Disease

Fried, M.; Abel, M; Pietruccha, D.; Bal, Aswine

doi:10.1097/00005176-199910000-00050

Cited by 4 publications

(5 citation statements)

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“…A study involving 15 patients diagnosed with Lyme disease, found that 10 patients had evidence of inflammation at a biopsy site with detection of B. burgdorferi DNA. Two of those patients had blood in their stool and presented with clinical features of Crohn's disease and ulcerative colitis [18].…”

Section: Association Of Morgellons With Spirochete Infectionmentioning

confidence: 99%

“…Factors like being female, Caucasian ethnicity, middle age, hypothyroidism and substance abuse were observed in MD patients although a causative relation has not been established [4] [16] [17]. One study concluded that most MD cases were found in California and Texas (18). Very little literature is found on the epidemiology of MD.…”

Section: Association Of Morgellons With Spirochete Infectionmentioning

confidence: 99%

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Dissociating Delusional Disorders and Infections from Dermatologic and Neurologic Effects of Morgellons Disease

Grimm¹,

Dolapihilla²,

Elapatha³

2021

AID

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Morgellons disease (MD) is a multi-system disorder characterized by multicolor filaments extruding out of the skin along with an array of dermatologic and neuropsychiatric symptoms. It was previously termed Delusional parasitosis. However, published scientific data found the association of MD symptoms with the systemic manifestations of Lyme disease, caused by Borrelia spirochete. In a retrospective study of 122 MD patients, skin specimens were examined and 96% of them showed Borrelia spirochete in their histology sample. Hence, this association suggests that spirochete infection could be a possible cause of chronic illness in MD patients, and this rejected the physician's perception that MD lesions might be self-inflicted. A cohort study reported tick-borne co-infections among MD patients, which could also be an etiological factor for dermopathy in MD patients. Some literature also discussed neuropsychiatric manifestations like cognitive impairment, dementia anxiety, depression, paranoia, and sensory hallucinations in Lyme disease and associated tick-borne infection. The objectives of this review are to identify the differences in the past and current perception regarding the pathogenesis of MD and determine the associations of spirochetal and tick-borne diseases with MD and psychiatric illnesses. More than 50 new research articles and case reports were reviewed and only 31 articles were shortlisted and used as references. This review has a detailed discussion on Morgellons disease and its association with Spirochete infection.

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Section: Association Of Morgellons With Spirochete Infectionmentioning

confidence: 99%

Section: Association Of Morgellons With Spirochete Infectionmentioning

confidence: 99%

Dissociating Delusional Disorders and Infections from Dermatologic and Neurologic Effects of Morgellons Disease

Grimm¹,

Dolapihilla²,

Elapatha³

2021

AID

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“…Clinical studies show evidence of persistent B. burgdorferi infection in humans [ 34 , 35 , 36 ]. Although there are some overlapping symptoms of CLD and acute Lyme disease, including pain, polyradiculoneuropathy [ 37 ] fatigue, and sleep disturbance [ 38 ], CLD causes some symptoms that differentiate it from acute Lyme disease, including functional and structural brain abnormalities [ 39 ], cognitive impairment [ 13 , 40 ], neuroborreliosis [ 14 ], musculoskeletal and neurological morbidity, vision impairment [ 41 ], depression [ 9 , 42 ] (which can lead to suicide) [ 43 ], cardiac issues (including Lyme carditis) [ 44 , 45 ], gastrointestinal issues [ 46 , 47 ], joint pain, and Lyme arthritis [ 48 , 49 ]. The number of Lyme disease patients with lingering symptoms in the US was projected to be as high as 1,944,189 in 2020 [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Medical Gaslighting and Lyme Disease: The Patient Experience

Fagen,

Shelton,

Luché-Thayer

2023

Healthcare

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Even though there are approximately half a million new cases of Lyme disease in the US annually, according to the CDC, it is often undiagnosed or misdiagnosed, which can result in a chronic, multisystemic condition. Lyme disease is a recognized public health threat and is a designated “notifiable disease”. As such, Lyme disease is mandated to be reported by the CDC. Despite this, both acute and chronic Lyme disease (CLD) have been relegated to the category of “contested illnesses”, which can lead to medical gaslighting. By analyzing results from an online survey of respondents with Lyme disease (n = 986), we elucidate the lived experiences of people who have been pushed to the margins of the medical system by having their symptoms attributed to mental illness, anxiety, stress, and aging. Further, respondents have had their blood tests and erythema migrans (EM) rashes discounted and were told that CLD simply does not exist. As a result, a series of fruitless consultations often result in the delay of a correct diagnosis, which has deleterious consequences. This is the first study that addresses an extensive range of gaslighting techniques experienced by this patient population.

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“…Until recently, B. burgdorferi was thought to be manifest in the skin, muscles, skeleton, cardiovascular system, eyes, central and periphery nervous system, genitourinary tract, lymphatic system, liver, kidneys, bronchi and lungs [16,41]. Recently, PCR was used on biopsies from the gastrointestinal (GI) tract to detect B. burgdorferi infection in the gut of patients with erythema migrans and gastrointestinal pain [15]. New insights into the life history of the bacterium show that the GI tract must be considered a sanctuary for this bacterium, implying insufficient treatment of Borrelia infections [15].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, PCR was used on biopsies from the gastrointestinal (GI) tract to detect B. burgdorferi infection in the gut of patients with erythema migrans and gastrointestinal pain [15]. New insights into the life history of the bacterium show that the GI tract must be considered a sanctuary for this bacterium, implying insufficient treatment of Borrelia infections [15].…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of motile and cystic forms of Borrelia burgdorferi to ranitidine bismuth citrate

Brorson

2001

Int Microbiol

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Gastrointestinal symptoms accompanying Lyme disease have not been considered in the treatment of Lyme patients yet. Here we examine the effect of ranitidine bismuth citrate (RBC) on motile and cystic forms of Borrelia burgdorferi in vitro, to determine whether it could cure this bacterial infection in the gastrointestinal tract. When motile forms of B. burgdorferi were exposed to RBC for 1 week at 37 degrees C, the minimal bactericidal concentration (MBC) was > 64 mg/ml. At 30 degrees C, the MBC was > 256 mg/ml. When the incubation lasted for 2 weeks at 37 degrees C, the MBC dropped to > 2 mg/ml. Bismuth aggregates were present on the surface of B. burgdorferi when RBC > or = MBC, as shown by transmission electron microscopy (TEM). Cystic forms of B. burgdorferi, exposed to RBC for 2 weeks at 37 degrees C, were examined by cultivation in BSK-H medium (Sigma B3528). They were stained with acridine orange (pH 6.4, pH 7.4) and studied by TEM. The MBC for RBC for young cystic forms (1 day old) and old cysts (8 months old) was estimated to be > 0.125 mg/ml and > 2 mg/ml, respectively. Bismuth aggregates were attached to the cysts and, in some, the pin-shaped aggregates penetrated the cyst wall. The bismuth aggregates also bound strongly to blebs and granules of B. burgdorferi when RBC > or = MBC. When B. burgdorferi is responsible for gastrointestinal symptoms, bismuth compounds may be candidates for eradication of the bacterium from the gastrointestinal tract.

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The Spectrum of Gastrointestinal Manifestations in Lyme Disease

Cited by 4 publications

References 0 publications

Dissociating Delusional Disorders and Infections from Dermatologic and Neurologic Effects of Morgellons Disease

Dissociating Delusional Disorders and Infections from Dermatologic and Neurologic Effects of Morgellons Disease

Medical Gaslighting and Lyme Disease: The Patient Experience

Susceptibility of motile and cystic forms of Borrelia burgdorferi to ranitidine bismuth citrate

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