The Spectrum of Cutaneous Manifestations in Lupus Erythematosus: The Tertiary Hospital Experience

Mowla, Mohammad Rafiqul; Alam, Mansurul; Hoque, Gofranul; Islam, Aqm Serajul; Dey, Nishit Ranjan; Hoque, Roksana; Datta, Pradip; Hasan, Suzon Al

doi:10.3329/jcmcta.v21i1.7668

Cited by 4 publications

(8 citation statements)

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“…Tables 1 and 2 A systematic literature search was conducted using PubMed and Google Scholar databases and 'urticaria' and 'systemic lupus erythematosus' as keywords, covering a period from 1950 to 2015. In most of the studies CSU or chronic urticarial rash in patients with SLE was termed 'chronic urticaria' [18,124], 'urticaria' [19][20][21][22][23]27,54,56,[125][126][127][128][129][130][131], 'urticarial eruptions of varying duration' [73], 'hives' [28,30,132,133], 'non-vasculitic urticaria' [25], 'urticarial lesions' [134,135] and 'chronic urticaria-like lesions' [26,53]. We did not include in the table reports where information on urticaria as a cutaneous manifestation of SLE was not reported in the paper [34, 74,136,137].…”

Section: Discussionmentioning

confidence: 99%

“…The distinction between CSU and UV was made only in some studies [25,35,53,55,57,58,124,138]. Many other studies had no clear differentiation between CSU and UV but the latter may have been termed 'vasculitis' [20,23,54,125,128,129], 'vasculitic rash' [139], 'dermal vasculitis' [28,133] or 'cutaneous vasculitis' [28,37,126,127,140] that allowed us to assume that most of the patients with urticarial rash in these studies are patients with CSU. Almost all authors in these studies used Gilliam and Sontheimer classification of SLE skin manifestations [32] that support this suggestion.…”

Section: Discussionmentioning

confidence: 99%

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Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus – a systematic review

Kolkhir

Pogorelov

Olisova

et al. 2016

Clin Experimental Allergy

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Chronic spontaneous urticaria (CSU) is a common mast cell-driven disease characterized by the development of wheals (hives), angioedema (AE), or both for > 6 weeks. It is thought that autoimmunity is a common cause of CSU, which is often associated with autoimmune thyroiditis, whereas the link to other autoimmune disorders such as systemic lupus erythematosus (SLE) has not been carefully explored. Here, we systematically reviewed the existing literature for information on the prevalence of CSU in SLE (and vice versa) and we examined the possible clinical and pathogenetic relationship between CSU and SLE. The prevalence of CSU and CSU-like rash in SLE was investigated by 42 independent studies and comorbidity in adult patients reportedly ranged from 0% to 21.9% and 0.4% to 27.5%, respectively (urticarial vasculitis: 0-20%). In children with SLE, CSU was reported in 0-1.2% and CSU-like rash in 4.5-12% (urticarial vasculitis: 0-2.2%). In contrast, little information is available on the prevalence of SLE in patients with CSU, and more studies are needed to determine the rate of comorbidity. Recent insights on IgG- and IgE-mediated autoreactivity suggest similarities in the pathogenesis of CSU and SLE linking inflammation and autoimmunity with the activation of the complement and coagulation system. Future studies of patients with either or both conditions could help to better define common pathomechanisms in CSU and SLE and to develop novel targeted treatment options for patients with CSU and SLE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus – a systematic review

Kolkhir

Pogorelov

Olisova

et al. 2016

Clin Experimental Allergy

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“…In LE-specific skin lesions, the most common manifestation was photosensitivity (91%). The prevalence of photosensitivity in the previous studies ranged from 28% to 95% [19,20]. CLE patients are photosensitive; therefore, disease prevalence might be higher in areas with more ambient sun exposure, such as Bangladesh.…”

Section: Discussionmentioning

confidence: 91%

Clinicopathological characteristics of cutaneous lupus erythematosus patients in Bangladesh

Mowla¹,

Barua²,

Zaman³

et al. 2022

pdia

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“…Although rare, keratoderma has been reported as a co-existent or incidental finding in patients with SLE in a few studies [1,4,8,[10][11][12]. In a Chittagong cross-sectional survey, palmoplantar keratoderma was found in 2.5% of SLE patients [10]. Keratoderma is a keratinizing disorder caused by genetic or acquired causes such as systemic diseases, infections, and cancer [6][7][8][9]13].…”

Section: Discussionmentioning

confidence: 99%

Keratoderma in Systemic Lupus Erythematosus: An Unusual Cutaneous Manifestation of Disease?

CA¹,

Bhanu²,

Dandu³

et al. 2022

Cureus

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Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease, with the skin being the second most affected organ after the joints. We present a unique case of a 44-year-old female who presented with an acute flare of SLE and the concurrent onset of keratoderma on both lower limbs. She presented with highgrade fever, arthralgia, and generalized edema of four months duration. A general physical examination revealed pallor and scaly hyperpigmented plaques on both lower limbs, which was confirmed to be keratoderma on histopathological examination. Blood investigations revealed pancytopenia, elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and positive titers for anti-nuclear antibody (ANA) and anti-Po ribosomal P proteins (RPP) antibodies. Immunosuppressive medications and topical keratolytics were used to treat her successfully. Post medical management, she showed significant improvement in her symptoms. On follow-up, the patient had a complete resolution of the symptoms and remained well. This case demonstrates keratoderma as a rare incidental finding in a patient with SLE flare. Understanding SLE's various cutaneous manifestations are critical for holistically diagnosing and treating the disease.

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The Spectrum of Cutaneous Manifestations in Lupus Erythematosus: The Tertiary Hospital Experience

Abstract: Key words: SLE; cutaneous; ChittagongDOI: 10.3329/jcmcta.v21i1.7668 Journal of Chittagong Medical College Teachers' Association 2010: 21(1):34-39

Cited by 4 publications

References 0 publications

Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus – a systematic review

Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus – a systematic review

Clinicopathological characteristics of cutaneous lupus erythematosus patients in Bangladesh

Keratoderma in Systemic Lupus Erythematosus: An Unusual Cutaneous Manifestation of Disease?

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