The Spectrum of Congenital Heart Defects in Infants with Down’S Syndrome, Khartoum, Sudan

Elshazali, Osama Hafiz; Ahmed, Hamed; Elshazali, Hafiz Osama Hafiz

doi:10.15406/jpnc.2015.02.00091

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…All of cases were of low birth weight with 50% being of very low birth weight. 13.5% of all cases were born with chromosomal abnormalities with the most common being Down syndrome followed by Noonan's syndrome ( Figure 1). The prevalence of Down syndrome in the study was 8.5% compared to 0.14% among the general population and 31.7% of the samples were of low birth weight [13].…”

Section: Resultsmentioning

confidence: 99%

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The relationship between birth weight and congenital heart disease at Ahmed Gasim Cardiac Centre, Bahri, Sudan

Elshazali

2017

Sudan J Paed

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Low birth weight is a known comorbidity of congenital heart disease (CHD). This study examines the relationship between CHD and birth weight of singletons, while attempting to remove factors that influence birth weight, and assesses the impact of CHD on growth in later life. The main objective is to study the relationship between birthweight and CHD. This is a cross-sectional study of 141 samples, covering all patients who were referred to the Paediatric Echocardiography Lab at Ahmed Gasim Cardiac Centre between September and October 2016. Infants with genetic syndromes or other major extracardiac abnormalities were excluded. The findings of this study clearly demonstrate that infants with CHD are more likely to be of low birth weight than the general Sudanese population, by a factor of 2.6. Of the sample, 31.9% were born with low or very low birthweight. The mean birth weight of the cases was 2.59 kg, which is 17.3% and 542.4 g less than the national average. CHD that cause a decrement in birth weight in a descending order of severity were atrial septal defect (-721 g/23%), patent ductus arteriosus (-669 g/21%), ventricular septal defect (-610 g/19%), pulmonary stenosis (-548 g/13%) and tetralogy of Fallot (248 g/8%). Pre/postnatal growth impairment is a common feature among children with CHD. No statistically significant relationship was found between the degree of birth weight/weight to age decrement and the specific type of hemodynamic disturbance. Our results are comparable to other studies that have been undertaken. However, Sudanese patients display larger birthweight deficits than other populations.

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Section: Resultsmentioning

confidence: 99%

“…There are almost no cases with positive family history. The Najmeddin study, which was performed in Sudan found family history to be positive in 7.8% patients; perhaps due to them using a different definition of family history of CHD (only first-degree relative were considered for this research) [13].…”

Section: Discussionmentioning

confidence: 96%

The relationship between birth weight and congenital heart disease at Ahmed Gasim Cardiac Centre, Bahri, Sudan

Elshazali

2017

Sudan J Paed

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“… 16 – 18 The recent rates from Libya, Sudan and Iran were 45%, 43.1% and 50%, respectively. 2 , 19 , 20 Rates from other countries ranged from 43% to 58%. 21 – 26 This variation in the prevalence of CHD in DS can be explained by differing screening programs and diagnostic facilities, and the genetic, socioeconomic and environmental variability of different study populations.…”

Section: Discussionmentioning

confidence: 99%

“… 19 In Sudan, Saudi Arabia, India and Western countries AVSD, VSD and ASD were the most frequent. 10 , 16 – 18 , 20 – 22 , 24 , 28 In Iran and Korea, ASD, VSD, PDA and AVSD were the commonest. 2 , 25 However, in Pakistan and Mexico, VSD and PDA were the commonest.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of congenital heart diseases in children with Down syndrome in Mansoura, Egypt: a retrospective descriptive study

El‐Gilany

Yahia

Wahba

2017

Annals of Saudi Medicine

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BACKGROUNDThe pattern and risk factors for congenital heart diseases (CHD) in children with Down syndrome (DS) vary over time.OBJECTIVESTo update knowledge of the prevalence, types, trends and associated factors for CHD in children with DS in the Egyptian Delta.DESIGNA retrospective hospital record-based descriptive study.SETTINGA tertiary care center in Mansoura, Egypt during a period of 14 years from 2003 up to 2016.PATIENTS AND METHODSWe studied children with genetically proven DS. Relevant sociodemographic factors, medical history, clinical examination, karyotype and echocardiographic data were statistically analyzed.MAIN OUTCOME MEASURESPrevalence, types and risk factors of CHD in DS.RESULTSThe prevalence of overall, isolated and multiple CHD in 1720 children with DS were 36.9%, 29% and 8%, respectively. Isolated defects accounted for 78.4% of all CHD. Ventricular septal defect, atrioventricular septal defect and atrial septal defect were the most frequent isolated defects. There was a downward trend in the prevalence of overall CHD (from 56.2% to 25.0%) and isolated CHD (from 56.2% to 19.8%). The logistic regression model predicted 65.7% of CHD and revealed that passive maternal smoking, lack of folic acid/multivitamin supplementation and parental consanguinity were the independent predictors of CHD in children with DS with adjusted odds ratios of 1.9, 1.8 and 1.9, respectively.CONCLUSIONMore than one-third of children with DS have CHD with ventricular septal defect, which is the most common. Avoidance of passive maternal smoking and consanguineous marriage together with maternal folic acid supplementation could contribute to further reduction of CHD in children with DS.LIMITATIONSSingle-center study and retrospective.

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“…[38][39][40] Recently rates in other countries as Libya, Sudan, and Iran were 45, 43.1, and 50%, respectively. [41][42][43] Rates from other countries ranged from 43 to 58%. 44,45 Variations in CHD prevalence in DS cases could be explained by many screening programs, diagnostic facility, genetic, socioeconomic, and environmental variability of different study populations.…”

Section: Dropped Patientsmentioning

confidence: 99%

Clinical Profiles, Congenital Heart Disease, and Other Comorbidities Among Egyptian Children with Down Syndrome: A Tertiary Center Study

Amin

Abdel-Meguid

El-Refaie

et al. 2021

Journal of Child Science

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Introduction Down syndrome (DS) is the most common chromosomal disorder. It is accompanied by several comorbidities, which could lead to severe morbidity and mortality. Congenital heart disease (CHD) is one of the most commonly described condition. Objective This study aimed to determine clinical profiles, dysmorphic features, CHD, and DS associated comorbidities in a tertiary center (Cairo, Egypt). Patients and Methods This descriptive study included 290 patients diagnosed with DS, who presented to the Clinical Genetics clinic, Cairo University Children Hospitals, from February 2018 to December 2019. The patients' ages ranged from 2 to 4 years old. All patients were evaluated by full history, clinical examination, anthropometric measurements, and assessment of developmental milestones. Patients' diagnostic investigations including karyotype, thyroid function, and echocardiography were checked. Results The study population consisted of 290 children with DS of which 196 (67.6%) were male, 115 (40%) had CHD, the most prevalent atrial septal defect (ASD), patent ductus arteriosus (PDA), and ventricular septal defect (VSD) accounting for 10.7, 7.1, and 4.2%, respectively. Common dysmorphic features were upward slanting palpebral fissures (98.6%), hypertelorism (97.9%), and sandal gap (60.7%). Thyroid dysfunction was the second prevalent comorbidity, found in 35 patients (12.1%). Global developmental delay was reported affecting language (99%), motor (94.8%), and social (92.8%) domains. Conclusion The prevalence of CHD among children with DS was 40% with ASD, PDA, and VSD being the commonest. Thyroid dysfunction was the second most common comorbidity. The most prevalent dysmorphic features were upward slanting palpebral fissures, hypertelorism, and sandal gap. Developmental delay was very common, language being the most affected domain.

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The Spectrum of Congenital Heart Defects in Infants with Down’S Syndrome, Khartoum, Sudan

Cited by 7 publications

References 16 publications

The relationship between birth weight and congenital heart disease at Ahmed Gasim Cardiac Centre, Bahri, Sudan

The relationship between birth weight and congenital heart disease at Ahmed Gasim Cardiac Centre, Bahri, Sudan

Prevalence of congenital heart diseases in children with Down syndrome in Mansoura, Egypt: a retrospective descriptive study

Clinical Profiles, Congenital Heart Disease, and Other Comorbidities Among Egyptian Children with Down Syndrome: A Tertiary Center Study

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