The spectrum of chronic kidney disease (stages 2–5) in KwaZulu-Natal, South Africa

Bhimma, Rajendra; Adhikari, Miriam; Asharam, Kareshma; Connolly, Catherine

doi:10.1007/s00467-008-0871-5

Cited by 38 publications

(35 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge none of the studies were reported exclusively on children in ESRD and therefore, our study adds important new information to the epidemiology of ESRD among Nigerian children. Our study showed that the incidence of paediatric ESRD was higher than previously reported from our sub region [1,2,13] but lower than those reported in developed countries [8,9,11,23]. Glomerulonephritis was the commonest cause, followed by CAKUT.…”

Section: Discussioncontrasting

confidence: 56%

“…There are few studies on childhood ESRD from sub-Saharan Africa [1,2,12,13]. To the best of our knowledge none of the studies were reported exclusively on children in ESRD and therefore, our study adds important new information to the epidemiology of ESRD among Nigerian children.…”

Section: Discussionmentioning

confidence: 85%

“…By contrast, paucity of such data exists in sub-Saharan Africa [1,2,12,13], without which, advocacy, development of intervention strategies, and evaluation of effectiveness of interventions are restricted. This study aims to make a contribution by determining current incidence, aetiology, management and outcomes of paediatric ESRD in a tertiary hospital in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria

et al. 2014

View full text Add to dashboard Cite

BackgroundChildren and adolescents with end-stage renal disease (ESRD) in sub-Saharan Africa may have the worst outcomes globally. Barriers to management include late presentation, poor socioeconomic conditions, absence of medical insurance, limited diagnostic facilities and non-availability of chronic renal replacement therapy (RRT). Our study was to determine the incidence, aetiology, management and outcomes of paediatric ESRD in a tertiary hospital in Nigeria.MethodsA retrospective case review of paediatric ESRD at the University College Hospital Ibadan, Nigeria, over 8 years, from January 2005 to December 2012.Results53 patients (56.6% male), median age 11 (inter quartile range 8.5-12) years were studied. Mean annual incidence of ESRD in Ibadan for children aged 14 years and below was 4 per million age related population (PMARP) while for those aged 5-14 years it was 6.0 PMARP. Glomerulonephritis was the cause in 41 (77.4%) patients amongst whom, 29 had chronic glomerulonephritis and 12 had nephrotic syndrome. Congenital anomalies of the kidneys and urinary tract (CAKUT) accounted for 11 (21.2%) cases, posterior urethral valves being the most common. Acute haemodialysis, acute peritoneal dialysis or a combination of these were performed in 33 (62.3%), 6 (11.3%) and 4 (7.5%) patients respectively. Median survival was 47 days and in-hospital mortality was 59%.ConclusionsIncidence of paediatric ESRD in Ibadan is higher than previous reports from sub-Saharan Africa. Glomerulonephritis, and then CAKUT are the most common causes. Mortality is high, primarily due to lack of resources. Preventive nephrology and chronic RRT programmes are urgently needed.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Single-center studies from sub-Saharan Africa have shown a very low incidence of CKD, estimated at 3 pmarp in Nigeria, which did not offer pediatric RRT, and 1–2 pmarp in South Africa [23, 24]. …”

Section: Demographics Of Ckdmentioning

confidence: 99%

Epidemiology of chronic kidney disease in children

et al. 2011

View full text Add to dashboard Cite

In the past 30 years there have been major improvements in the care of children with chronic kidney disease (CKD). However, most of the available epidemiological data stem from end-stage renal disease (ESRD) registries and information on the earlier stages of pediatric CKD is still limited. The median reported incidence of renal replacement therapy (RRT) in children aged 0–19 years across the world in 2008 was 9 per million of the age-related population (4–18 years). The prevalence of RRT in 2008 ranged from 18 to 100 per million of the age-related population. Congenital disorders, including congenital anomalies of the kidney and urinary tract (CAKUT) and hereditary nephropathies, are responsible for about two thirds of all cases of CKD in developed countries, while acquired causes predominate in developing countries. Children with congenital disorders experience a slower progression of CKD than those with glomerulonephritis, resulting in a lower proportion of CAKUT in the ESRD population compared with less advanced stages of CKD. Most children with ESRD start on dialysis and then receive a transplant. While the survival rate of children with ERSD has improved, it remains about 30 times lower than that of healthy peers. Children now mainly die of cardiovascular causes and infection rather than from renal failure.Electronic supplementary materialThe online version of this article (doi:10.1007/s00467-011-1939-1) contains supplementary material, which is available to authorized users

show abstract

“…Nephrotic syndrome was also observed as the most common etiology of CKD in KwaZulu-Natal, South Africa, with 30.9% in children aged < 5 years and 40.8% in children > 5 years. 12 The prevalence of ESRD at presentation in our study was 21.8%. This number is much lower than that found in the studies in Turkey (32.5%) 4 and Sudan (63%).…”

Section: Resultsmentioning

confidence: 42%