2021
DOI: 10.4103/jhrs.jhrs_165_20
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The Spectrum of Chromosomal Abnormalities and Endocrine Profile of Male Infertility with Nonobstructive Semen Abnormality

Abstract: Background: Primary infertility is a common occurrence which affects approximately 15% of couples who desire to begin their family. Chromosomal abnormalities are well-established causes of pregnancy loss but may also have a role in explaining the cause of male infertility, especially with nonobstructive semen abnormalities. Hence, awareness regarding safety of artificial reproductive technology in these individuals due to underlying sperm aneuploidy is required. Aims: T… Show more

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Cited by 3 publications
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“…Genetic testing has become increasingly prevalent in male infertility screening and includes testing for whole-chromosomal structural aberrations, partial chromosomal defects, and monogenic diseases [ 10 ]. In men with azoospermia, genetic screening has revealed a higher incidence of constitutional karyotypic abnormalities [ 11 ]. Detection of Y-microdeletions can also identify genetic relationships of impaired spermatogenesis, which would not only remarkably limit reproductive competence, but would also be passed on to male offspring once assisted reproductive technologies (ART) are used [ 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…Genetic testing has become increasingly prevalent in male infertility screening and includes testing for whole-chromosomal structural aberrations, partial chromosomal defects, and monogenic diseases [ 10 ]. In men with azoospermia, genetic screening has revealed a higher incidence of constitutional karyotypic abnormalities [ 11 ]. Detection of Y-microdeletions can also identify genetic relationships of impaired spermatogenesis, which would not only remarkably limit reproductive competence, but would also be passed on to male offspring once assisted reproductive technologies (ART) are used [ 12 ].…”
Section: Introductionmentioning
confidence: 99%