The specificity of ultrasound-detected bone erosions for rheumatoid arthritis

Zayat, Ahmed S; Ellegaard, Karen; Conaghan, Philip G.; Terslev, Lene; Hensor, Elizabeth M A; Freeston, Jane; Emery, Paul; Wakefield, Richard J.

doi:10.1136/annrheumdis-2013-204864

Cited by 86 publications

(65 citation statements)

References 32 publications

(15 reference statements)

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“…However, as shown by Zayat, et al, the presence of any erosive changes in the fifth MTP was specific for RA 61 . It should be pointed out that some of the included papers in this review 15,35,39,48,51,53 contain a small number of patients and therefore their importance lies more in supporting evidence from larger studies and demonstrating the development of US in erosion diagnostics and monitoring.…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

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Summary Findings of a Systematic Literature Review of the Ultrasound Assessment of Bone Erosions in Rheumatoid Arthritis

et al. 2015

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Section: Journal Of Rheumatologymentioning

confidence: 99%

“…Discrimination: Responsiveness. Sensitivity to change was assessed in 11 studies and in 2 of them, a reduction in size of erosions in the evaluated joints was reported 55,61 . In 6/11 studies, where sensitivity to change was studied, erosive changes were described as present/absent.…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

Summary Findings of a Systematic Literature Review of the Ultrasound Assessment of Bone Erosions in Rheumatoid Arthritis

et al. 2015

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“…Zayat et al [28] searched for erosions in multiple sites of the hands and feet of patients with RA, psoriatic arthritis (PsA), gout and healthy individuals, at the level of the foot focusing on 1 st and 5 th MTP. They found that erosions in RA patients are more frequent comparing with other groups but are not specific for RA [sensitivity (Se) 91.4%, specificity (Sp) 32.9%].…”

Section: Metatarsophalangeal (Mtp) Joints Synovial Hypertrophy and Efmentioning

confidence: 99%

The relevance of ultrasound examination of the foot and ankle in patients with rheumatoid arthritis – a review of the literature

2019

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Rheumatoid arthritis (RA) is an inflammatory disease characterized by symmetrical involvement of the joints and tendons, especially of the hands and wrists, but also of the feet and ankles from the very beginning of the disease. For the patient, the foot and ankle involvement is equally important as the other joints, since it affects the functionality of the feet and the quality of life of the patients. It is already known that subclinical involvement of the ankles and feet occurs even in patients that are considered in clinical remission, thus they do not need for changes of therapy, but still might benefit from it. In spite of this, the clinicians do not give enough care to the ankle and foot in RA patients, especially if asymptomatic, resulting future deformities, joint damage and feet disability. In order to show the importance of the feet and ankles in RA patients and to demonstrate the indispensable role of ultrasonography (US) for that purpose, at the same time displaying the US abnormalities that should draw our attention, we performed this review of the literature.

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“…This fact may suggest that the studied patients were observed at an early stage of the disease, before the above-mentioned changes could appear [12,25]. In our research, erosions most frequently appeared in MTP II, but the majority of reports demonstrate the involvement of MTP V and IP in early RA [12,15,31].…”

Section: Discussionmentioning

confidence: 50%

“…Erosions on joint surfaces -in accordance with the definition proposed by OMERACT, discontinuity of the cortical bone surface, that was visualized in at least two perpendicular planes [15,16]. The presence of erosions was assessed on a 2-grade scale: 0 -lack of erosions, 1 -erosions present.…”

Section: Reumatologia 2015; 53/4mentioning

confidence: 99%

The initial ultrasonographic examination of hands and feet joints in patients with early rheumatoid arthritis

Ponikowska¹,

Wiland²

2015

Reumatologia

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Objectives: The aim was to assess of the morphology, intensity, and activity of changes in the first ultrasonographic (US) examination of hands and feet in patients with early arthritis (lasting up to 12 months) who were ultimately diagnosed with rheumatoid arthritis (RA). An attempt was made to demonstrate a correlation between the intensity of lesions in US and selected laboratory parameters. Material and methods: Ultrasonographic examination was performed using a LOGIC GE 500 device on a group of 60 patients with arthritis (46 women, 14 men) aged 18-80, previously untreated. In total, 3120 hand and feet joints were examined. The assessment focused on the presence of joint effusion, synovial proliferation and power Doppler signals (assessed on a semi-quantitative scale). Each patient underwent laboratory tests, necessary for making a diagnosis. In order to analyze the correlations between changes in US and laboratory parameters, erythrocyte sedimentation rate (ESR), reactive protein test (CRP), rheumatoid factor (RF), and anti-citrullinated protein antibodies (ACPAs) were used. Results: In the study group, the average duration of arthritis symptoms until the first US examination was 5.6 months. Among the 3120 examined hand and foot joints, deviations from the norm appeared in 1093 joints, synovial hypertrophy was found in 471 joints (grade 1 synovial hypertrophy was reported most frequently), while presence of signal in Power Doppler was revealed in 261 joints (grade 1 was observed most frequently). A statistically significant correlation was found between the intensity of changes in Power Doppler and CRP concentration. Conclusions: In patients with increased concentrations of CRP, we may expect arthritis of higher intensity, therefore, in order to prevent the progression of destructive changes, it is necessary to quickly implement effective disease-modifying antirheumatic treatment. The conducted research showed that the activity of joint inflammation is not affected by the values of ESR and the presence of RF or ACPAs.

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The specificity of ultrasound-detected bone erosions for rheumatoid arthritis

Abstract: The presence of US-detected erosions is not specific for RA. However, larger erosions in selected joints, especially 2nd and 5rd MCP, 5th MTP joints and distal ulna, were highly specific for and predictive of RA.

Cited by 86 publications

References 32 publications

Summary Findings of a Systematic Literature Review of the Ultrasound Assessment of Bone Erosions in Rheumatoid Arthritis

Summary Findings of a Systematic Literature Review of the Ultrasound Assessment of Bone Erosions in Rheumatoid Arthritis

The relevance of ultrasound examination of the foot and ankle in patients with rheumatoid arthritis – a review of the literature

The initial ultrasonographic examination of hands and feet joints in patients with early rheumatoid arthritis

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