The Specificity of the C D C-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria

Kennedy, Gwen; Abbot, NC; Spence, V. A.; Underwood, Christine; Belch, J. J. F.

doi:10.1016/j.annepidem.2003.10.004

Cited by 42 publications

(19 citation statements)

References 36 publications

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“…Hill et al (1999) also found that mode of illness onset was not predictive of positive or negative illness outcomes. Kennedy et al (2004) suggested that patients be separated into precipitating factors surrounding onset because there are significant differences in clinical symptoms among those whose CFS began after military service, after exposure to organophosphate insecticides, and others who developed CFS sporadically. Another category worth considering is after exposure to an infectious disease.…”

Section: Sociodemographic Psychosocial and Illness Subtypesmentioning

confidence: 97%

Chronic Fatigue Syndrome: The Need for Subtypes

et al. 2005

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Chronic fatigue syndrome (CFS) is an important condition confronting patients, clinicians, and researchers. This article provides information concerning the need for appropriate diagnosis of CFS subtypes. We first review findings suggesting that CFS is best conceptualized as a separate diagnostic entity rather than as part of a unitary model of functional somatic distress. Next, research involving the case definitions of CFS is reviewed. Findings suggest that whether a broad or more conservative case definition is employed, and whether clinic or community samples are recruited, these decisions will have a major influence in the types of patients selected. Review of further findings suggests that subtyping individuals with CFS on sociodemographic, functional disability, viral, immune, neuroendocrine, neurology, autonomic, and genetic biomarkers can provide clarification for researchers and clinicians who encounter CFS' characteristically confusing heterogeneous symptom profiles. Treatment studies that incorporate subtypes might be particularly helpful in better understanding the pathophysiology of CFS. This review suggests that there is a need for greater diagnostic clarity, and this might be accomplished by subgroups that integrate multiple variables including those in cognitive, emotional, and biological domains.

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Section: Sociodemographic Psychosocial and Illness Subtypesmentioning

confidence: 97%

Chronic Fatigue Syndrome: The Need for Subtypes

et al. 2005

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“…The prevalence of CFS is difficult to ascertain, largely as a result of two factors. First, the condition in itself is difficult to diagnose, because of the significant overlap between symptoms of CFS and those of other chronic conditions (Kennedy, Abbot, Spence, Underwood, & Belch, 2004); and second, clinicians vary in their use of diagnostic criteria. Despite this, recent estimates suggest that 150,000 people in the UK suffer from the condition ( Jason et al, 1997), or 0.3-2.6% of the UK population (Campion et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Stigma and the delegitimation experience: An interpretative phenomenological analysis of people living with chronic fatigue syndrome

Dickson

Knussen

Flowers

2007

Psychology & Health

109

115

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Individual in-depth interviews with 14 people with chronic fatigue syndrome (CFS) were conducted, focusing on the experience of living with CFS. The interviews were transcribed verbatim and were analysed for recurrent themes using interpretative phenomenological analysis (IPA). Here we present two inter-related themes: ''Negotiating a diagnosis'' and ''Negotiating CFS with loved ones''. Participants reported delay, negotiation and debate over diagnosis: further, they perceived their GPs to be sceptical, disrespectful and to be lacking in knowledge and interpersonal skills. However, participants found delegitimising encounters with their partners more difficult to deal with. Participants viewed such delegitimation as a form of personal rejection; they were hurt by their loved ones' reactions and subsequently pondered the price of love, respect and friendship. The findings are discussed in relation to extant literature, and recommendations for future research are suggested.

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“…[26,27] This heterogeneity has been demonstrated among distinct patient sets that all fulfill the definition, but are based on widely different clinical measures. [28] In contrast, the CCC and ICC have been shown to select cases with more severe impairments in physical and social functioning. [29][30][31] With respect to severity, the International Consensus Primer [11] was the first to suggest categories of illness impact, wherein mild cases show significant reductions in pre-morbid activity levels, moderate cases experience a 50% reduction, severe cases are mostly housebound, and very severely affected patients are largely bedridden and require assistance.…”

Section: Clinical Heterogeneitymentioning

confidence: 96%

The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings

Johnston

Brenu

Staines

et al. 2013

Fatigue: Biomedicine, Health & Behavior

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Background: Chronic fatigue syndrome, also known as myalgic encephalomyelitis (CFS/ME) is a particularly difficult illness to identify. To aid in classifying patients for research as well as clinical care, potential cases may be evaluated according to clinical guidelines. Purpose: The purpose of this paper is to provide an overview of three sets of guidelines currently available: the Centers for Disease Control and Prevention (CDC) Toolkit; the International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME) Primer; and the International Consensus Primer. Methods: These guidelines were examined and compared with respect to required symptoms, laboratory and investigative protocols, and exclusionary and comorbid conditions. The comparisons were also intended to evaluate the guidelines in light of new research that advances the clinical understanding of CFS/ME and assists in identifying patients. Results: Guidelines vary significantly in the symptoms and comorbidities considered in light of the differing symptom requirements of three case definitions. There is also no specification on how symptoms should be measured, contributing to the significant heterogeneity found in CFS/ME. Conclusions: Further revision of clinical guidelines, preferably based on a definition that is well-informed by current empirical studies, is recommended to ensure that guidelines are applied with consistency and understanding in both research and clinical settings.

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The Specificity of the C D C-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria

Cited by 42 publications

References 36 publications

Chronic Fatigue Syndrome: The Need for Subtypes

Chronic Fatigue Syndrome: The Need for Subtypes

Stigma and the delegitimation experience: An interpretative phenomenological analysis of people living with chronic fatigue syndrome

The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings

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