The species of genus fagonia in Libya: (A comprehensive review)

Abstract

The Plants of the genus Fagonia have been broadly utilized as adjunctive therapy, to treat several conditions involving high fever, diabetes, asthma, stoma chache, dental pain, and renal problems using their aqueous extracts as medicines. This genus is a valuable source that comprises a variety of Triterpenes, flavonoids, and Saponins. The herbal chemistry as well as the biological action of Fagonia species have been a candidate for many researchers. The in vivo pharmacological screening of their extracts has manifested some other significant properties such as cytotoxic and anti-cancer activity. This review study has gathered the important research that has been carried out on the species that grow in Libya. It includes an exhaustive survey of literature about the medicinal value and the bioactivities of various extracts obtained from these Fagonia species using references from major databases.

Evaluation of the Therapeutic Anti-Carcinogenic Effect of Fagonia Arabica on Oral Squamous Cell Carcinoma (An in Vitro Study)

“…This suggests that FASEE has a potent cytotoxic effect against Ehrlich carcinoma (11). In contrast to the results of the current study, Alamami et al reported that an alcoholic and aqueous extracts of Fagonia taeckholmiana revealed no significant anti-carcinogenic effect on neither human liver carcinoma cells (HEPG2) nor human glioblastoma cells (U-251) (26). In addition, Albalawi et al concluded that an extract of Fagonia tenuifolia had little anti-cancer effect on non-small cell lung cancer cells (NCI-H460) (27).…”

“…Flavonoids have been found to possess anti-mutagenic and anti-malignant properties. Additionally, flavonoids contribute to cancer chemoprevention through their impacts on angiogenesis and signal transduction in cell growth (26). A number of trials were executed in order to detect the effective dose of Fagonia arabica.…”

“…Many factors are proposed to contribute to variation in the anticancer effect of different Fagonia species on different cancer forms. Such factors include diversity in the phytochemical structure of different Fagonia species, type of tumor, tumor characteristics, and some tumors show low sensitivity to certain Fagonia species as they don't show positive expression for the related molecular pathways (26). Cisplatin is an essential chemotherapeutic agent that is considered the most commonly used drug in the treatment of OSCC (4,28,29).…”