The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse
Kathryn Frost,
Jonathan W. Lewis,
Simon W. Jones
et al.
Abstract:The deterioration of osteoblast-led bone formation and the upregulation of osteoclast-regulated bone resorption are the primary causes of bone diseases, including osteoporosis. Numerous circulating factors play a role in bone homeostasis by regulating osteoblast and osteoclast activity, including the sphingolipid—sphingosine-1-phosphate (S1P). However, to date no comprehensive studies have investigated the impact of S1P activity on human and murine osteoblasts and osteoclasts. We observed species-specific resp… Show more
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