The Spatiotemporal Dynamics of Autobiographical Memory: Neural Correlates of Recall, Emotional Intensity, and Reliving

Daselaar, Sander M.; Rice, Heather J.; Greenberg, Daniel; Cabeza, Roberto; LaBar, Kevin S.; Rubin, David C.

doi:10.1093/cercor/bhm048

Cited by 299 publications

(336 citation statements)

References 111 publications

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“…37,38 A week's treatment with reboxetine decreased activation during recognition of positive vs negative personality-trait words in an area of the right medial frontal cortex (BA 6) similar to acute administration of reboxetine seen previously 15 (MNI coordinates x = 10, y = À10, z = 62 (current report), MNI coordinates x = 20, y = À14, z = 60 (single-dose reboxetine study)). Engagement of right medial frontal cortex (BA6) during memory retrieval has been previously reported 39 and is suggested to be greater during recognition compared to recall tasks. 40 Greater activation in right medial frontal cortex (BA 6) during retrieval of self-referentially processed personalitytrait words has also been reported.…”

Section: Reboxetine and Subsequent Recognitionmentioning

confidence: 79%

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

et al. 2007

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Recent neuropsychological studies in healthy volunteers suggest that antidepressants enhance the processing of positive emotional information. However, the neural substrates underpinning these changes have not been fully elucidated. The current study, therefore, used functional magnetic resonance imaging (fMRI) to map brain systems activated during successful categorization and subsequent recognition of self-referent positive and negative personality characteristics in healthy volunteers following short-term (7 days) repeated administration of the selective noradrenergic reuptake inhibitor reboxetine. Twenty-four healthy volunteers were randomly assigned to 7-day double-blind intervention with reboxetine or placebo. On day 7, neural responses during the categorization and subsequent recognition of positive and negative characteristics were assessed using fMRI. Questionnaires monitoring mood, hostility and anxiety were given before and during this intervention. During categorization, reboxetine was associated with greater activation to positive words, relative to negative words, in left precuneus and right inferior frontal gyrus. By contrast, at subsequent recognition reboxetine was associated with reduced response to positive words, relative to negative words, in left precuneus, anterior cingulate and medial frontal gyrus. These changes in the neural processing of positive and negative words occurred in the absence of significant differences in ratings of mood and anxiety. Such adaptations in the neural processing of emotional information support the hypothesis that antidepressants have early effects on emotional processing in a manner which would be expected to reverse negative biases in depression.

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Section: Reboxetine and Subsequent Recognitionmentioning

confidence: 79%

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

et al. 2007

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“…Previous fMRI studies have shown that the episodic recall of life events (episodic autobiographical memory) relies on a distributed set of brain regions that includes the hippocampus, the lateral temporal cortices, the temporo-parietal junction, the medial prefrontal cortex, the precuneus, and the retrosplenial cortex (28)(29)(30). The actual contents of the memory representation are believed to be stored in the cortex, with different cortical regions dynamically linked by the hippocampus during successful episodic encoding and retrieval (28,29,(31)(32)(33). A recent neuroimaging study showed modulation of hippocampal activation by the level of rehearsal of a given autobiographical memory.…”

Section: A B Cmentioning

confidence: 99%

Out-of-body–induced hippocampal amnesia

Bergouignan

Nyberg

Ehrsson

2014

Proc. Natl. Acad. Sci. U.S.A.

160

192

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Theoretical models have suggested an association between the ongoing experience of the world from the perspective of one's own body and hippocampus-based episodic memory. This link has been supported by clinical reports of long-term episodic memory impairments in psychiatric conditions with dissociative symptoms, in which individuals feel detached from themselves as if having an out-of-body experience. Here, we introduce an experimental approach to examine the necessary role of perceiving the world from the perspective of one's own body for the successful episodic encoding of real-life events. While participants were involved in a social interaction, an out-of-body illusion was elicited, in which the sense of bodily self was displaced from the real body to the other end of the testing room. This condition was compared with a well-matched in-body illusion condition, in which the sense of bodily self was colocalized with the real body. In separate recall sessions, performed ∼1 wk later, we assessed the participants' episodic memory of these events. The results revealed an episodic recollection deficit for events encoded out-of-body compared with in-body. Functional magnetic resonance imaging indicated that this impairment was specifically associated with activity changes in the posterior hippocampus. Collectively, these findings show that efficient hippocampus-based episodic-memory encoding requires a first-person perspective of the natural spatial relationship between the body and the world. Our observations have important implications for theoretical models of episodic memory, neurocognitive models of self, embodied cognition, and clinical research into memory deficits in psychiatric disorders.self-consciousness | body illusion | dissociative experience | autobiographical memory

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“…Increased activations in healthy controls were also observed in the somatosensory regions during the elaboration phase (vs. the construction phase), not evident in the patient group. In the AM literature, the somatosensory cortex is closely linked to the retrieval of somatosensory representations related to the event, the emotional intensity, and is also especially engaged during the elaboration of events (Daselaar et al 2008;Botzung et al 2010). …”

Section: Fig 4 Significant Brain Activations For the Group X Task Inmentioning

confidence: 99%

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

Ernst

Noblet

Denkova

et al. 2015

Brain Imaging and Behavior

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Mental time travel (MTT) entails the ability to mentally travel into autobiographical memory (AM) and episodic future thinking (EFT). While AM and EFT share common phenomenological and cerebral functional properties, distinctive characteristics have been documented in healthy and clinical populations. No report, to our knowledge, has informed on the functional underpinnings of MTT impairment in multiple sclerosis (MS) patients, hence the aim of this work. We studied 22 relapsing-remitting MS patients and 22 matched controls. Participants underwent an AM/EFT assessment using the Autobiographical Interview (Levine et al. 2002), followed by a functional MRI session. The latter consisted in AM and EFT tasks, distinguishing the construction and elaboration phases of events. The results showed impaired performance for AM and EFT in patients, accompanied by increased cerebral activations mostly located in the frontal regions, which extended to the parietal, lateral temporal and posterior regions during AM/EFT tasks, relative to healthy controls. Enhanced brain activations in MS patients were particularly evident during the EFT task and involved the hippocampus, frontal, external temporal, and cingulate regions. The construction phase required greater fronto-parieto-temporal activations in MS patients relative to both healthy controls, and the elaboration phase. Taking together, our results suggested the occurrence of cerebral activation changes in the context of MTT in MS patients, expressed by distinct and common mechanisms for AM and EFT. This study may provide new insights in terms of cerebral activation changes in brain lesion and their application to clinical settings, considering AM/EFT's central role in everyday life.

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The Spatiotemporal Dynamics of Autobiographical Memory: Neural Correlates of Recall, Emotional Intensity, and Reliving

Cited by 299 publications

References 111 publications

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

Out-of-body–induced hippocampal amnesia

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

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