The spatial and temporal repeatability of PHA-responses

Granbom, Martin; Råberg, Lars; Smith, Henrik G.

doi:10.1093/beheco/arh137

Cited by 13 publications

(8 citation statements)

References 17 publications

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Section: Methodsmentioning

confidence: 99%

“…In European starlings (Sturnus vulgaris), the repeatability between the left and right wing injected at the same time (i.e. spatial repeatability) was highly significant (Granbom et al, 2005), suggesting that the swelling response represents a repeatable measure within an individual. Moreover, several cross-fostering studies have revealed an effect of nest of origin, indicating a genetic component of PHA response (Saino et al, 1997;Brinkhof et al, 1999;Soler et al, 2003;Ardia, 2005).…”

Section: Pha Assaymentioning

confidence: 99%

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Cell‐mediated immunity and multi‐locus heterozygosity in bluethroat nestlings

Fossøy

Johnsen

Lifjeld

2009

J of Evolutionary Biology

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Recent evidence suggests that marker‐based heterozygosity‐fitness correlations may be driven by only one or a few markers, indicating local heterozygosity effects caused by linkage disequilibrium with functional genes. In this study, we investigated the relationship between microsatellite heterozygosity and a measure of cell‐mediated immunity (phytohaemagglutinin; PHA) in bluethroat (Luscinia s. svecica) nestlings using a full‐sibling design. We found significant positive associations between PHA response and two different indices of microsatellite heterozygosity, i.e. multi‐locus heterozygosity and mean d2. However, model comparisons disclosed that both associations were more likely caused by local effects rather than general effects and that the two local effects appeared to be realized through two different genetic mechanisms. Our results indicate that both the random assortment of parental chromosomes during meiosis as well as inbreeding can drive heterozygosity‐fitness correlations.

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Section: Methodsmentioning

confidence: 99%

Section: Pha Assaymentioning

confidence: 99%

Cell‐mediated immunity and multi‐locus heterozygosity in bluethroat nestlings

Fossøy

Johnsen

Lifjeld

2009

J of Evolutionary Biology

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“…Hence our repeatability estimate combines variation from measurement error (estimated as 0.6 to 0.9 by Örnborg et al 2002) and spatial variability within the crown. For a similar example focusing on repeatability of cell‐mediated immune response see Granbom et al (2005).…”

Section: Methodsmentioning

confidence: 99%

Age differences in blue tit Parus caeruleus plumage colour: within‐individual changes or colour‐biased survival?

Delhey¹,

Kempenaers²

2006

Journal of Avian Biology

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In many species of passerine birds yearlings display a less elaborate version of the adult secondary sexual traits, but the causes of such differences in ornamentation are not always well understood. We studied age‐related changes in blue tit Parus caeruleus UV/blue structural crown coloration, a sexually selected trait. In our Austrian study population, older blue tits, irrespective of sex, displayed on average a more ultraviolet (lower hue, higher UV chroma), more chromatic and brighter crown coloration than yearlings. This age dichromatism was caused by within‐individual changes in the expression of crown coloration between years since males and females became more UV, more chromatic and brighter as they aged. Colour biased survival did not contribute to the observed pattern of age dichromatism since crown coloration was largely unrelated to overwinter survival. Between‐year repeatability of crown colour was significant for most colour variables but low in general, and lower for females than for males. In the blue tit, yearling males might benefit from being less ornamented by avoiding adult aggression but at the expense of sexual attractiveness. Adaptive explanations of blue tit age dichromatism should however take into account that age effects were of similar magnitude in males and females. This suggests that both male and female yearlings could benefit from being less ornamented and hence that sexual selection might be acting on both sexes simultaneously in this species.

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“…Because chicks were injected on both wings, the total amount of PHA was 1 mg and 0.5 mg for 2003 and 2004, respectively. Granbom and colleagues showed that the spatial repeatability of PHA swellings between both wings is relatively low and to improve the accuracy of the test, both wings should be injected with PHA (Granbom et al, 2005). Smits and colleagues showed that it is not required to use a control injection of saline to accurately assess the response to PHA (Smits et al, 1999).…”

Section: Cell-mediated Immunity: Pha Challengementioning

confidence: 99%

Yolk androgens and the development of avian immunity: an experiment in jackdaws (Corvus monedula)

Sandell

Tobler

Hasselquist

2009

Journal of Experimental Biology

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SUMMARYMaternally derived androgens have been shown to influence offspring phenotype in various ways. In birds, the benefits of prenatal androgen exposure, such as increased competitiveness and accelerated growth in nestlings, have been suggested to be balanced by costs, such as reduced immune function. In this study, we used an integrative approach to examine the influence of yolk androgens on the development of immune function in jackdaw (Corvus monedula) nestlings. Specifically, we tested whether the effects of yolk androgens on offspring immunity may extend over the first few days of life and be detectable even after several weeks. We manipulated yolk androgen concentrations in jackdaw eggs and estimated immune responsiveness by challenging the young with different pathogens at different stages of the nestling period. Six-day-old chicks hatched from eggs with elevated yolk androgen levels had lower pre-challenge antibody titres against lipopolysaccharide (LPS) than control chicks. However, antibody titres against LPS did not differ between treatment groups eight days after a challenge with LPS. During the late nestling phase, both humoral (towards diphtheria/tetanus antigens) and cell-mediated (towards phytohaemagglutinin) immune responsiveness were lower in chicks from yolk androgen-treated eggs compared with control chicks. Our experimental study on jackdaw chicks shows that elevated yolk androgen levels result in a general immunosuppression in offspring; this conclusion was based on results for several immunological tests of both humoral and cell-mediated immunity conducted at 1-2 and 3-4 weeks of age.

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The spatial and temporal repeatability of PHA-responses

Cited by 13 publications

References 17 publications

Cell‐mediated immunity and multi‐locus heterozygosity in bluethroat nestlings

Cell‐mediated immunity and multi‐locus heterozygosity in bluethroat nestlings

Age differences in blue tit Parus caeruleus plumage colour: within‐individual changes or colour‐biased survival?

Yolk androgens and the development of avian immunity: an experiment in jackdaws (Corvus monedula)

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