The spasmolytic activity of the essential oil of <i>Thymus baeticus</i> boiss in rats

Cruz, T.; Jiménez, J.; Zarzuelo, Antonio; Cabo, M. M.

doi:10.1002/ptr.2650030308

Cited by 8 publications

(5 citation statements)

References 4 publications

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“…These results, thus, suggest that EoWs operated as an agonist through one of the two muscarinic receptor contraction pathways. Similar observations were done with plant extracts from Nepeta cataria L. [28], Satureja hortensis [29], and Satureja obavata [30].…”

Section: Discussionsupporting

confidence: 76%

The Antispasmodic Effect of Warionia saharae Essential Oil in Experimental Models and its Mechanism of Action

Aziz¹,

Marghich²,

Addi³

et al. 2022

Front. Biosci. (Schol Ed)

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With several medicinal and aromatic species, the Asteraceae family is one of the largest angiosperm families. The genus Warionia is represented in this family by only one species, Warionia saharae. In Moroccan traditional medicine, this species is widely used to treat gastrointestinal problems. Essential oil of this plant (EoWs) was studied for possible myorelaxant and antispasmodic activities to rationalize some of the traditional uses. In this investigation, hydrodistillation was used to obtain the essential oil from the aerial part of the dry plant extract (EoWs), which was then analyzed using gas chromatography coupled to mass spectrometry (GC/MS). The major compounds identified in the EoWs are nerolidyl acetate (21.44%), β-Eudesmol (19.47%), linalool (16.48%), 1-terpinene-4-ol (10.93%), and cineole (5.34%). EoWs is relatively safe in the case of acute intake up to 2 g/kg body weight of albino mice. The effect of EoWs on intestinal relaxation was investigated using rabbit and rat jejunal smooth muscle. We have noticed that EoWs produce a myorelaxation on basal rabbit jejunum's contractions in a concentration-dependent manner with a maximal effect at 30 µg/mL. This myorelaxation was not dependent on adrenergic receptors. When the rat jejunums were pre-contracted with 25 mM KCl or 10 µM Carbachol (CCh), EoWs had an antispasmodic action with an IC50 values of 15.76 ± 0.37 and 12.04 ± 0.30 µg/mL, respectively. Preliminary results showed that it is probable that our plant might act directly through the NO and guanylate cyclase signaling pathway and on muscarinic but not nicotinic receptors. The results reveal that the Essential oil of W. saharae appears to have an impact on intestinal relaxation in vitro conditions. This finding lends credence to the traditional usage of this plant to treat intestinal disorders.

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Section: Discussionsupporting

confidence: 76%

The Antispasmodic Effect of Warionia saharae Essential Oil in Experimental Models and its Mechanism of Action

Aziz¹,

Marghich²,

Addi³

et al. 2022

Front. Biosci. (Schol Ed)

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“…Finally, it is also an interesting therapeutic option in ophthalmic disorders, against inflammation and infection in external parts of the eye (conjunctiva, lacrimal sac, cornea, and edges of the eyelids) (46). As for Thymus vulgaris, the active compound present in the essential oil exhibits anthelmintic, antibacterial and antifungal properties (47), as well as antispasmodic activity (48). Moreover, it may be useful against bronchospasm (49) and as mucolytic (50), which may explain its wide use in chronic bronchitis.…”

Section: Resultsmentioning

confidence: 99%

“…As for Thymus vulgaris , the active compound present in the essential oil exhibits anthelmintic, antibacterial and antifungal properties ( 47 ), as well as antispasmodic activity ( 48 ). Moreover, it may be useful against bronchospasm ( 49 ) and as mucolytic ( 50 ), which may explain its wide use in chronic bronchitis.…”

Section: Resultsmentioning

confidence: 99%

Use of medicinal plants by veterinary practitioners in Spain: A cross-sectional survey

et al. 2022

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Medicinal plants have been used in veterinary medicine since ancient times, and they are gaining importance in Eastern Europe. The aim of this study was to conduct a survey on the use of medicinal plants in Spain. A cross-sectional study with an online questionnaire was carried out among Spanish small animal veterinarians, to evaluate the use patterns of medicinal plants and attitudes of professionals toward it. 313 veterinarians took part in the study. Most of them were female (80.2%) and age ranged 35–49 (49.5%). 80.3% of respondents use phytotherapy. Musculoskeletal and gastrointestinal disorders were those most frequently treated, with cannabis, aloe and thyme the most often medicinal plants used. The most common pattern of user was women working in clinics.

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“…The inhibitory effect may be explained by inhibition of Ca 2+ entry into smooth muscle through voltage-stimulated channels and/or blocking Ca 2+ release into smooth muscle and/or blocking intracellular bound Ca 2+ release. [67][68][69][70] The species with the highest FL values (FL=100%) for the treatment of digestive tract diseases are Ceratonia siliqua L., Anacyclus pyrethrum L., Calendula arvensis L., Jasminum officinale L., Olea europea L. var. sylvestris (Hoffmanns & Link) Negodi, Prasium majus L., Quercus ilex L., Ruta chalepensis L. and Thymus Zygis L..…”

Section: Fidelity Levelmentioning

confidence: 99%

Quantitative and Qualitative Ethnobotanical Study of Medicinal Plants used in Oulmes Region, Morocco for the Treatment of Diseases and Infections

2023

TJNPR

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on the strength of these qualities, the plant gene pool known for its originality is estimated at about 4500 vascular plants species distributed between 41 ecosystems, 6 of which 640 species (16%) and 280 subspecies (32%) are Moroccan endemics. 7 These factors have allowed the country to be among the Mediterranean countries that have a great ancestral know-how in phytotherapy. 8,9 Furthermore, the ancestry of medicinal plants used by the Moroccan population for the treatment of diseases, 8,10 is due to the low cost of plants widely available, but also, in the belief by the miraculous virtues of these plants in the treatment of various diseases, and that these plants are natural products and do not present toxic effects. 11,12 The Oulmes region in Morocco has a poverty rate ranging from 5,89% to 6,46% for the communes of Oulmés and Ait Ichou respectively. Health facilities and services are limited to three dispensaries for a population scattered in 62 douars, 13 and with fairly modest transport infrastructure. These elements make traditional medicine the first resort for the local population. 14 Indeed, given that the popular knowledge in traditional pharmacopoeia is currently held by few people who have a high rate of illiteracy, 15 and the great interest of this field in chemical industry and synthetic chemistry 16 that has known in recent decades, there is a renewed interest in the study of medicinal plants and their popular use in various regions of Morocco. 17,18 Nevertheless, studies on this aspect at the level of the Moroccan central plateau remain timid and have been limited to works at the level of the central messeta 19,20 or would only focus on the qualitative aspect . 21 That is why we tried to achieve an ethnobotanical study, both qualitative

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The spasmolytic activity of the essential oil of Thymus baeticus boiss in rats

Cited by 8 publications

References 4 publications

The Antispasmodic Effect of Warionia saharae Essential Oil in Experimental Models and its Mechanism of Action

The Antispasmodic Effect of Warionia saharae Essential Oil in Experimental Models and its Mechanism of Action

Use of medicinal plants by veterinary practitioners in Spain: A cross-sectional survey

Quantitative and Qualitative Ethnobotanical Study of Medicinal Plants used in Oulmes Region, Morocco for the Treatment of Diseases and Infections

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