The Soy Isoflavones for Reducing Bone Loss (SIRBL) Study: a 3-y randomized controlled trial in postmenopausal women

Alekel, D. Lee; Loan, Marta D. Van; Koehler, Kenneth J.; Hanson, Laura; Stewart, Jeanne W; Hanson, Kathy B.; Kurzer, Mindy S.; Peterson, Charles T.

doi:10.3945/ajcn.2009.28306

Cited by 145 publications

(93 citation statements)

References 64 publications

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“…Soy isoflavones were shown to attenuate bone loss from the lumbar spine in perimenopausal women, 4 possibly by stimulating bone formation 4,30 or inhibiting bone resorption. 30,31 Other studies, however, have not substantiated these beneficial effects on bone mineral density (BMD) 32,33 or biochemical markers of bone. 33 The effect of soy consumption on thyroid status is also of interest because four decades ago, goiter was reported in infants fed soy formula that was not fortified with iodine.…”

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confidence: 99%

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

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Background: Soy foods have been substituted for meat in recent years because of proposed health benefits. Research indicates, however, that soy protein and phytate in soy products inhibit the absorption of divalent cations. Methods: Our study was primarily designed to determine the effect of consuming two to three servings per day of soy foods, providing *19 g protein and *36 mg isoflavones, on iron and zinc status in premenopausal women during a 10-weeks period. As secondary outcomes, we also tested the effect of soy foods on biochemical markers of bone and thyroid hormones. Nonsmoking women (18-28 years) without chronic disease, anemia, pregnancy, or irregular menstrual cycles were randomly assigned to either the soy food (SF, n = 31) or animal food (AF, n = 32) group. Blood and urine samples and 3-day dietary records were collected at baseline and postintervention. Results: At baseline, iron and zinc status, bone markers, and thyroid hormones were not different between groups. After intervention, no significant changes were observed in hemoglobin, transferrin saturation, serum iron, ferritin, or transferrin receptor (TFR) concentrations. Plasma zinc, but not serum alkaline phosphatase, significantly decreased in both groups ( -0.8 lmol/L).

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confidence: 99%

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

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“…However, the mechanisms by which these benefits are effected are unknown-benefits, however, have been debated, as demonstrated by the controversial effects of isoflavone on bone density in postmenopausal women (Ma et al 2008;Brink et al 2008;Alekel et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

Hong

Ahn

et al. 2012

Genes Nutr

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Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equol production on health in Koreans and identified the genetic factors that determine the equol-producing phenotype. In 1391 subjects, the equol-producing phenotype was determined, based on measurements of serum equol concentrations. The anthropometric and blood biochemical measurements between equol producers and nonproducers were analyzed by LC-MS/MS. Genetic factors were identified in a genomewide association study (GWAS), and the interaction between genetic factors and the equol-producing phenotype was examined. We observed that 70.1 % of the study population produced equol. Blood pressure was significantly lower in equol producers (beta ± SE = -1.35 ± 0.67, p = 0.045). In our genomewide association study, we identified 5 single-nucleotide polymorphisms (p \ 1 9 10 -5 ) in HACE1. The most significant SNP was rs6927608, and individuals with a minor allele of rs6927608 did not produce equol (odds ratio = 0.57 (95 % CI 0.45-0.72), p value = 2.5 9 10 -6 ). Notably, the interaction between equol production and the rs6927608 HACE1 SNP was significantly associated with systolic blood pressure (p value = 1.3 9 10 4 ). Equol production is linked to blood pressure, and HACE1, identified in our (GWAS), might be a determinant of the equol-producing phenotype.

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“…Khan (2012) specifically investigated breast epithelial cell proliferation, which was presumed to be beneficially influenced by isoflavones. In six studies (Alekel 2010, Maskarinec 2009/Steinberg 2011, Chilibeck 2013, Levis 2011/D'Anna 2013and Lappe 2013) the primary aim, at least of the original study, was the (presumed beneficial) effect on bone parameters. In two studies (Evans 2011, Geller 2009), the primary endpoint was (presumed relief of) menopausal symptoms.…”

Section: Results Objective 1: Human Studiesmentioning

confidence: 99%

Preparatory work to support the risk assessment for peri‐ and postmenopausal women taking food supplements containing isolated isoflavones

Tijhuis

Doets

Velpen

et al. 2015

EFSA Supporting Publications

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Suggested citation: M Tijhuis, E Doets, V van der Velpen and M Vonk Noordegraaf-Schouten, 2015; Preparatory work to support the risk assessment for peri-and postmenopausal women taking food supplements containing isolated isoflavones. ABSTRACTThe aim of this review was to identify the scientific data from January 2009 till December 2013 on effects of isolated isoflavones from food supplements on reproductive organs (breast, uterus) and thyroid of menopausal women. A search in PubMed, Web of Science, CAB Abstracts and Embase (search date: February 7 th 2014), resulted in 2,497 unique hits. Based on title and abstract, 177 articles were eligible for full text selection. Of these, 95 were human studies (objective 1), 68 were animal studies (objective 2) and 14 contained data on both. Hand search yielded no additional articles. After full text screening, for objective 1, 14 articles met our inclusion criteria for data extraction; for objective 2, 17 met our inclusion criteria for data-extraction and 7 were included for mapping purposes; from articles with data for objective 1 and 2 combined, all 14 were excluded. All included studies were intervention studies. A grey literature search resulted in 1 relevant risk assessment published by a national body. Uterus was the most studied target organ for both objectives; the most prevalent outcomes were endometrial thickness for objective 1 and uterine weight for objective 2. Under objective 2, no studies evaluating thyroid were identified. Studies under objective 1 did not report adverse effects related to isoflavone supplementation, studies under 2 were less consistent. Many methodological issues exist, such as the scarcity of long-term human data and studies aimed at detecting adverse effects; and issues of metabolic differences between species and dose translation from animals to humans.

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The Soy Isoflavones for Reducing Bone Loss (SIRBL) Study: a 3-y randomized controlled trial in postmenopausal women

Abstract: Our results do not show a bone-sparing effect of extracted soy isoflavones, except for a modest effect at the femoral neck. This trial was registered at clinicaltrials.gov as NCT00043745.

Cited by 145 publications

References 64 publications

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

Preparatory work to support the risk assessment for peri‐ and postmenopausal women taking food supplements containing isolated isoflavones

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