The Sources and Modes of Infection

Ernst, Harold C.

doi:10.1126/science.34.868.215

Cited by 2 publications

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“…Droplets settled on surfaces of fomites are considered as one of the most significant modes of microbial infection transmission [1,2]. The surface of fomites contaminated with bacterial pathogens is found to be responsible for the outbreak of community-acquired and nosocomial infections.…”

Section: Main Textmentioning

confidence: 99%

“…4 and 5). Thus, bacterial chemotactic velocity is negligible in such small time-scale and hence neglected in the above eqn (1). Moreover, as the flow dynamics in droplet evaporation is convection dominant, therefore by scaling analysis, diffusion term (O(10 −14 )) also becomes negligible in comparison to the transient term (O(10 5 ) and advective term O(10 2 )).…”

Section: Mathematical Modeling Model A: Spatio-temporal Variation In Bacterial Concentrationmentioning

confidence: 99%

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Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

Majee

Chowdhury

Pinto

et al. 2021

Preprint

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Naturally drying bacterial droplets on inanimate surfaces representing fomites are the most consequential mode for transmitting infection through orofecal route. We provide a multiscale holistic approach to understand flow dynamics induced bacterial pattern formation on fomites leading to pathogenesis. The most virulent gut pathogen, Salmonella Typhimurium (STM), typically found in contaminated food and water, is used as model system in the current study. Evaporation-induced flow in sessile droplets facilitates the transport of STM, forming spatio-temporally varying bacterial deposition patterns based on droplet medium nutrient scale. Mechanical and low moisture stress in the drying process, reduced bacterial viability but interestingly induced hyper-proliferation of STM in macrophages, augmenting virulence in fomites. In vivo studies of fomites in mice confirm that STM maintains virulence. This work demonstrates that stressed bacterial deposit morphologies formed over small timescale (minutes) on organic and inorganic surfaces, plays significant role in enhancing fomite pathogenesis over hours and days.

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Section: Main Textmentioning

confidence: 99%

Section: Mathematical Modeling Model A: Spatio-temporal Variation In Bacterial Concentrationmentioning

confidence: 99%

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

Majee

Chowdhury

Pinto

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

et al. 2021

View full text Add to dashboard Cite

Naturally drying bacterial droplets on inanimate surfaces representing fomites are the most consequential mode for transmitting infection through oro-fecal route. We provide a multiscale holistic approach to understand flow dynamics induced bacterial pattern formation on fomites leading to pathogenesis. The most virulent gut pathogen, Salmonella Typhimurium (STM), typically found in contaminated food and water, is used as model system in the current study. Evaporation-induced flow in sessile droplets facilitates the transport of STM, forming spatio-temporally varying bacterial deposition patterns based on droplet medium’s nutrient scale. Mechanical and low moisture stress in the drying process reduced bacterial viability but interestingly induced hyper-proliferation of STM in macrophages, thereby augmenting virulence in fomites. In vivo studies of fomites in mice confirm that STM maintains enhanced virulence. This work demonstrates that stressed bacterial deposit morphologies formed over small timescale (minutes) on organic and inorganic surfaces, plays a significant role in enhancing fomite’s pathogenesis over hours and days.

show abstract

The Sources and Modes of Infection

Cited by 2 publications

References 0 publications

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

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