The source and action of histamine in the isolated guinea-pig gallbladder

Jennings, L. J.; Salido, Ginés M.; Pozo, Marı́a J.; Davison, Joseph S.; Sharkey, Keith A.; Lea, Robert; Singh, Jaipaul

doi:10.1007/bf01757702

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…MC degranulation results in a decreased threshold for the pain response with balloon distension and this hyperalgesic response can be prevented with MC-stabilizing medication [21] MC may also create gallbladder symptoms through the generation of gallbladder spasm. Two MC products, histamine and leukotrienes, have been shown to increase the excitability of gallbladder smooth muscle and lead to contraction [22-25]. We were unable to demonstrate a correlation between MC density or activation and the ejection fraction although this may be the result of the sensitivity of the method employed.…”

Section: Discussionmentioning

confidence: 62%

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

et al. 2011

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BackgroundThe current study was undertaken to determine the degree of activation of gallbladder mucosal mast cells, whether mast cell (MC) density or activation differ between patients with and without a positive clinical response to cholecystectomy, and whether either density or activation correlate with gallbladder emptying.ResultsFifteen biliary dyskinesia (BD) and 13 symptomatic cholelithiasis (CL) patients undergoing cholecystectomy were prospectively enrolled. Gallbladder wall MC density (by immunohistochemistry) and activation (by electron microscopy) were determined. Clinical response was evaluated 30 days post-cholecystectomy on a 5-point Likert-type scale. A complete or nearly complete clinical response was seen in 100% of CL and in 87% of BD patients. The overall degranulation indices were 49.4 ± 18.7% for CL patients and 44.2 ± 16.8% for BD patients. Neither MC density nor activation correlated with the gallbladder ejection fraction. A complete clinical response was associated with lower epithelial MC density.ConclusionCholecystectomy is efficacious in relieving pain in both CL and BD patients. BD and CL are associated not only with increased MC density but a moderate to high degree of MC activation. A possible relationship between MC density and outcome for BD warrants further investigation.

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Section: Discussionmentioning

confidence: 62%

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

et al. 2011

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“…Gallbladder mast cells would have the potential to contribute to pain generation by at least 2 mechanisms: sensitivity to distension as seen with mast cell degranulation in the gastrointestinal tract and through the generation of gallbladder spasms induced by mast cell products. For example, both histamine and cysteinyl leukotrienes increase the excitability of gallbladder smooth muscle and lead to contraction [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Gallbladder wall inflammatory cells in pediatric patients with biliary dyskinesia and cholelithiasis: a pilot study

Rau

Friesen

Daniel

et al. 2006

Journal of Pediatric Surgery

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“…Substances involved in inflammation processes can strongly influence gallbladder contractility 117–122. Increased proportion of arachidonyl‐phosphatidylcholine species (PLA 2 activity, PGE 2 ), as a marker of gallbladder mucosal inflammation and mucin concentrations, are found in the animal model fed a lithogenic diet 123.…”

Section: Bile Composition and Gallbladder Motilitymentioning

confidence: 99%

Coordinate regulation of gallbladder motor function in the gut-liver axis

et al. 2008

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Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%-15% in adults living in the western world, where cholesterol-enriched gallstones represent 75%-80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease. Indeed, a fine coordinated hepatobiliary and gastrointestinal function, including gallbladder motility in the fasting and postprandial state, is of crucial importance to prevent crystallization and precipitation of excess cholesterol in gallbladder bile. Also, gallbladder itself plays a physiopathological role in biliary lipid absorption. Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation. 47:2112-2126 G allstones are one the most common gastrointestinal diseases that require hospitalization in the western world, 1 and this is a true health burden 2-4 with enormous costs estimated at 6.5 billion dollars each year in United States. 4,5 Because life expectancy and the incidence rate of obesity are both rising worldwide, 6 the incidence rate of gallstones may increase, often in the context of the "metabolic syndrome". 7 The estimated prevalence of gallstones is 10%-15% in the general population of developed countries. In the United States, approximately 20 million to 25 million adults have gallstones. The burden of the disease is highest (60%-70%) in American Indians followed by Hispanics of mixed Indian origin. In contrast, the rate is lowest (less than 5%) in Asian and African populations. 5 The prevalence is intermediate (10%-15%) in Caucasians in developed countries. In Europe, the Multicenter Italian Study on Cholelithiasis (MICOL) ultrasonographic survey, which was performed across Italy including 29,000 subjects aged 30-69 years, reported an overall prevalence rate of 18.8% and 9.5% in women and men, respectively. 8 Major risk factors for the development of gallstones have been better identified over the past years and include age, female sex, some genetic polymorphisms within a background of a complex genetic disorder, pregnancy, obesity and rapid weight loss on low caloric diets or fol-

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The source and action of histamine in the isolated guinea-pig gallbladder

Cited by 19 publications

References 27 publications

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

Gallbladder wall inflammatory cells in pediatric patients with biliary dyskinesia and cholelithiasis: a pilot study

Coordinate regulation of gallbladder motor function in the gut-liver axis

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