The Sound of Silence: Hidden Responses of Neural Circuits to Alzheimer-Linked Mutations

Abstract

Dysfunctions of cortico-hippocampal circuits represent a hallmark of Alzheimer's disease. In this issue of Neuron, Jun et al. illuminate the spatial coding failures by familial Alzheimer's disease mutations that may underlie the progressive decline in spatial mnemonic processing.

Hippocampal sub-networks exhibit distinct spatial representation deficits in Alzheimer’s disease model mice

“…66 While this controversy is not yet fully resolved, it has been speculated that factors such as mouse model, method of measurement, and behavioral state (anesthetized or freely moving) offer resolution. 67 The effect of time interval on spatial representation dynamics in our task remains largely unclear. A potential contributing factor to the effect of time has been previously hypothesized and studied.…”