The sorption of nitroglycerin by infusion sets

Rudder, D. De; Remon, Jean‐Paul; Neyt, E N

doi:10.1111/j.2042-7158.1987.tb03178.x

Cited by 11 publications

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References 1 publication

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“…It is reasonable to assume, however, that sorption of nitroglycerin into the tube caused the difference in plasma nitroglycerin concentration and arterial pressure, according to the types of materials used in the tubes, as several in vitro studies on sorption of nitroglycerin into the tube have been carried out. [ 5 , 6 ] A sampling of drug from the administration set can also interfere in measuring the plasma concentration and the effect of the drug. Second, we had a small sample size (9 volunteers).…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, the possibility of nitroglycerin sorption into administration set tubes composed of polyvinyl chloride (PVC), polyurethane (PU), or polyolefin (PO) has been discussed. [ 5 , 6 ] Park et al [ 7 ] showed PO administration set prohibited drug sorption when compared to the PVC and PU administration set; however, these were in vitro studies. Altavela et al [ 8 ] also revealed that patients who received intravenous nitroglycerin through a PVC administration set had the same clinical response as patients given the drug through a polyethylene set.…”

Section: Introductionmentioning

confidence: 99%

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A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set

Kim

Song²,

Min

et al. 2018

Medicine

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Background:There is a risk of drug sorption into an intravenous administration set composed of polyvinyl chloride (PVC), polyurethane (PU), or polyolefin (PO). This has implications on the dose of the active ingredient the patient receives, and thus therapeutic success. This study aimed to determine the plasma concentration of nitroglycerin and the effect of nitroglycerin on patients based on the composition of the administration set.Methods:Using a randomized, open-labeled, 3 × 3 crossover method, 9 volunteers were assigned to 3 groups. In period I, nitroglycerin (100 μg/mL) was infused via a PVC- (group A), PU- (group B), or PO-based (group C) administration set. In period II, PU- (group A), PO- (group B), and PVC-based (group C) administration sets were used, and in period III, PO- (group A), PVC- (group B), and PU-based (group C) administration sets were used. The rate of drug administration in all periods was 12 mL/hour for 30 minutes using an infusion pump. Blood samples were collected, and the plasma concentrations of nitroglycerin were analyzed using validated high-performance liquid chromatography coupled with tandem mass spectrometry. Blood pressure was determined using a sphygmomanometer applied to the other upper arm at an interval of 5 minutes.Results:We observed that the mean plasma concentration of nitroglycerin over time when administered using a PO-based tube was higher than that when using a PU- or PVC-based tube. When the percent change of the mean arterial pressure from baseline at each time point was compared among groups, there were statistically significant differences between PU and PO or PVC at most points during nitroglycerin infusion.Conclusion:Our results showed higher nitroglycerin plasma concentration and lower arterial pressure when a PO-based administration set was used than when a PVC- or PU-based administration set was used. PO-based administration sets may be more appropriate for nitroglycerin administration compared to those composed of PVC or PU.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set

Kim

Song²,

Min

et al. 2018

Medicine

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“…Several authors have studied the problem of sorption of drugs by different kinds of infusion bags, administration sets and end-line filters. The presence of sorption has been reported for a wide variety of drugs such as nitroglycerin, isosorbide dinitrate, nimodipine, diazepam, to name but a few (Rusmin et a1 1977;Cossum & Roberts 1981;Kowaluk et a1 1981;Illum & Bundgaard 1982;D'Arcy 1983;Lee 1985;Jakobsen & Mikkelsen 1986;De Rudder et al 1987;De Muynck et a1 1988). Cutie & Lordi (1980) reported that verapamil, a calcium antagonist, was not sorbed by commonly used infusion fluid containers.…”

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confidence: 98%

The availability of diltiazem: A study on the sorption by intravenous delivery systems and on the stability of the drug

Vroe

Muynck

Remon

et al. 1989

Journal of Pharmacy and Pharmacology

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The stability and the sorption by intravenous delivery systems of the calcium antagonist diltiazem dissolved into either 5% dextrose or 0.9% sodium chloride solutions have been investigated, under conditions simulating current clinical practice. Static experiments showed an excellent stability and no sorption after 48 h. Dynamic experiments, at a perfusion rate of 20 mg h-1, showed no sorption of the drug by infusion fluid containers, burettes or administration sets. For end-line filters a temporary decrease of the recovered amount of diltiazem was observed but only with the 0.9% NaCl solution. It is concluded that the stability and the sorption of diltiazem offers no problem with regard to clinical efficacy.

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Basic Mechanisms of Action of Nitrovasodilators and Development of Tolerance to Organic Nitrates

Voorde¹,

Bogaert²

2000

Textbook of Angiology

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The sorption of nitroglycerin by infusion sets

Cited by 11 publications

References 1 publication

A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set

A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set

The availability of diltiazem: A study on the sorption by intravenous delivery systems and on the stability of the drug

Basic Mechanisms of Action of Nitrovasodilators and Development of Tolerance to Organic Nitrates

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