The SORG nomogram accurately predicts 3‐ and 12‐months survival for operable spine metastatic disease: External validation

Pereira, Nuno Rui Paulino; McLaughlin, Lily; Janssen, Stein J.; Dijk, C. Niek van; Bramer, Jos A. M.; Laufer, Ilya; Bilsky, Mark H.; Schwab, Joseph H.

doi:10.1002/jso.24620

Cited by 74 publications

(40 citation statements)

References 26 publications

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“…[17] The SORG nomogram also performed very well in our international cohort with an AUC of 0.87 for 90-days and 0.76 for 1-year. These findings are even more encouraging when compared with the results from Nater et al [10] that showed an AUC of 70 for 3-months and 0.78 for 12-months for the best predictive tool among nine different scoring systems or even from Paulino Pereira and Bongers et al [20,18] These facts also mean that this study is the first to show a clear advantage of the SORG at one year, compared with the Tokuhashi.…”

Section: Discussionsupporting

confidence: 73%

“…Our hypothesis is that, as partially demonstrated previously, [16,20,18,19] the SORG nomogram and ML are better predictive tools than the Tokuhashi Original or Revised scores for spinal metastatic disease survival at 3 months and 1 year. This international validation followed the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD).…”

Section: Methodsmentioning

confidence: 53%

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SORG Algorithm to Predict 3- and 12-month Survival in Metastatic Spinal Disease: A Cross-Sectional Population-Based Retrospective Study.

Zegarek

Tessitore

Chaboudez

et al. 2021

Preprint

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In this study, we recruited 40 patients with spinal metastatic disease who were operated at Geneva University Hospitals by the Neurosurgery or Orthopedic teams between the years of 2015 and 2020. We did an ROC analysis in order to determine the accuracy of the SORG ML algorithm and nomogram versus the Tokuhashi Original and Revised Scores. The analysis of data of our independent cohort shows a clear advantage in terms of predictive ability of the SORG ML algorithm and nomogram in comparison with the Tokuhashi scores. The SORG ML had an AUC of 0.87 for 90-days and 0.85 for 1-year. The SORG Nomogram showed a predictive ability at 90-days and 1-year with AUC’s of 0.87 and 0.76 respectively. These results showed excellent discriminative ability as compared with the Tokuhashi Original Score which achieved AUC’s of 0.70 and 0.69 and the Tokuhashi Revised Score which had AUC’s of 0.65 and 0.71 for 3-month and 1-year respectively. The predictive ability of the SORG ML algorithm and nomogram were superior to currently used preoperative survival estimation scores for spinal metastatic disease.

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Section: Discussionsupporting

confidence: 73%

Section: Methodsmentioning

confidence: 53%

SORG Algorithm to Predict 3- and 12-month Survival in Metastatic Spinal Disease: A Cross-Sectional Population-Based Retrospective Study.

Zegarek

Tessitore

Chaboudez

et al. 2021

Preprint

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“…Furthermore, well established scoring systems such as the Bauer, 35 New England Spinal Metatasis, 36 Katagiri, 37 Sioutos, 7 SORG, 38 Tokuhashi, 39 Tomita, 40 van der Linden 41 and others 6 , 42 currently incorporate measures of preoperative metastatic tumour burden by assessing the number of spine metastasis, other non-spine bone metastasis and visceral metastasis. However, despite controlling for these and other factors, serum alkaline phosphatase remained an independent prognostic factor on multivariable analysis; in addition, visceral metastasis no longer reached significance after incorporation of serum alkaline phosphatase.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of serum alkaline phosphatase in spinal metastatic disease

et al. 2019

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BACKGROUND: Determination of the appropriateness of invasive management in patients with spinal metastatic disease requires accurate pre-operative estimation of survival. The purpose of this study was to examine serum alkaline phosphatase as a prognostic marker in spinal metastatic disease. METHODS: Chart reviews from two tertiary care centres were used to identify spinal metastatic disease patients. Bivariate and multivariate analyses were used to determine if serum alkaline phosphatase was an independent prognostic marker for survival. RESULTS: Overall, 732 patients were included with 90-day and 1-year survival of n = 539 (74.9%) and n = 324 (45.7%), respectively. The 1-year survival of patients in the first quartile of alkaline phosphatase (≤73 IU/L) was 78 (57.8%) compared to 31 (24.0%) for patients in the fourth quartile (>140 IU/L). Preoperative serum alkaline phosphatase levels were significantly elevated in patients with multiple spine metastases, non-spine bone metastasis, and visceral metastasis but not in patients with brain metastasis. On multivariate analysis, elevated serum alkaline phosphatase was identified as an independent prognostic factor for survival in spinal metastatic disease. CONCLUSION: Serum alkaline phosphatase is associated with preoperative metastatic tumour burden and is a biomarker for overall survival in spinal metastatic disease.

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“…The SORG nomogram has demonstrated great accuracy in estimating survival at 3 months and 12 months for patients with operable spinal metastasis. 56 Its accuracy in predicting 3-, 6- and 12-month survival was 90%, 71% and 78%, respectively. 56 It is also amongst the limited scores showing good discriminative ability, consistently displaying an area under curve above 0.70 in receiver operating characteristic analysis for various time frames.…”

Section: Survival Predictionmentioning

confidence: 96%

“…The Skeletal Oncology Research Group (SORG) nomogram is a model composed of age, primary tumour type, Eastern Cooperative Oncology Group (ECOG) performance scale, presence of brain/visceral metastasis, number of spinal metastases, laboratory markers (white blood cell count and haemoglobin) and previous systemic treatment. 56 The risk magnitude of each factor is weighted from the value individually measured in the specific evaluated patient. The SORG nomogram has demonstrated great accuracy in estimating survival at 3 months and 12 months for patients with operable spinal metastasis.…”

Section: Survival Predictionmentioning

confidence: 99%

Spinal metastasis: narrative reviews of the current evidence and treatment modalities

Jaipanya

Chanplakorn

2022

J Int Med Res

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The treatment for spinal metastasis has evolved significantly during the past decade. An advancement in systemic therapy has led to a prolonged overall survival in cancer patients, thus increasing the incidence of spinal metastasis. In addition, with the improved treatment armamentarium, the prediction of patient survival using traditional prognostic models may have limitations and these require the incorporation of some novel parameters to improve their prognostic accuracy. The development of minimally-invasive spinal procedures and minimal access surgical techniques have facilitated a quicker patient recovery and return to systemic treatment. These modern interventions help to alleviate pain and improve quality of life, even in candidates with a relatively short life expectancy. Radiotherapy may be considered in non-surgical candidates or as adjuvant therapy for improving local tumour control. Stereotactic radiosurgery has facilitated this even in radioresistant tumours and may even replace surgery in radiosensitive malignancies. This narrative review summarizes the current evidence leading to the paradigm shifts in the modern treatment of spinal metastasis.

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The SORG nomogram accurately predicts 3‐ and 12‐months survival for operable spine metastatic disease: External validation

Abstract: The SORG nomogram accurately estimated 3- and 12-months survival for operable spine metastatic disease, and is therefore, useful in clinical practice.

Cited by 74 publications

References 26 publications

SORG Algorithm to Predict 3- and 12-month Survival in Metastatic Spinal Disease: A Cross-Sectional Population-Based Retrospective Study.

SORG Algorithm to Predict 3- and 12-month Survival in Metastatic Spinal Disease: A Cross-Sectional Population-Based Retrospective Study.

Prognostic value of serum alkaline phosphatase in spinal metastatic disease

Spinal metastasis: narrative reviews of the current evidence and treatment modalities

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