The soluble form of the IL-2 receptor (sCD25) as a novel biomarker for hepatocellular carcinoma.

Assessment of the Level of Soluble CD25 as a Marker for the Detection of Hepatocellular Carcinoma in Chronic Hepatitis C virus (HCV) Infected Patients

“…This analysis found that s CD25 possess a sensitivity of 65% at a cutoff value of >10.22 x 10 3 (pg/ml) for the presence of HCC and a specificity of 65.0% at the same cutoff value and warrants an additional investigation as a potential screening test. This do not come in agreement with Ararat et al (2011) (20) who reported that at a cutoff value of > 5.15 x10 3 (pg/ml), sCD25 has a sensitivity of 62.1% and a specificity of 83.3%, our results are lower this may be due to genetic difference, environmental factors and duration of HCC. When comparing s CD25 with AFP we found that the specificity of AFP (80.0%) was higher than that of s CD25 (65.0%).…”

“…This was not in agreement with Caberera et al (2012) (17) , who reported that the levels of s CD25 were significantly higher in patients with HCC than in normal group and than in patients with liver cirrhosis. A study done by Ararat et al (2011) (20) , Showed that the level of s CD25 in the serum of HCC patients was significantly higher (mean 12799 pg/ml) than that in the patients with cirrhosis (mean 3585 pg/ml). This analysis found that s CD25 possess a sensitivity of 65% at a cutoff value of >10.22 x 10 3 (pg/ml) for the presence of HCC and a specificity of 65.0% at the same cutoff value and warrants an additional investigation as a potential screening test.…”