The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila and cellular models of Alzheimer's disease
Xiaowen Sun,
Wei Li,
Lin Li
et al.
Abstract:Background
Alzheimer's disease (AD) is a common neurodegenerative disease, and its pathogenesis is closely associated with neuroinflammation. The control of neuroinflammation in AD is the focus of current research. sEH is increased in the brain tissues of patients with AD, and sEH induces nerve inflammation by degrading epoxyeicosatrienoic acids (EETs). Therefore, sEH inhibitor application and sEH gene knockout are effective ways to improve the bioavailability of EETs and inhibit neuroinflammation in AD. TPPU… Show more
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