The solitary pulmonary nodule

Tang, Anzhou; Moss, Hilary; Robertson, Ross

doi:10.1016/s0720-048x(02)00297-8

Cited by 60 publications

(32 citation statements)

References 66 publications

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“…Many studies have shown that spiculated and lobulated edges are suggestive of malignancy [37][38][39]. However, a predominantly smooth nodule is usually related to either a benign lesion, such as hamartoma, or metastasis in patients with a history of malignancy [40].…”

Section: Discussionmentioning

confidence: 99%

Correlation of radio- and histomorphological pattern of pulmonary adenocarcinoma

et al. 2012

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Recently, a novel classification system based on tumour architecture and with high prognostic impact has been proposed for pulmonary adenocarcinomas (ADCs). For imagingbased prediction of histological ADC subtypes and, thus, prognosis, it is of paramount importance to investigate the correlations of radio-and histomorphological parameters.Associations between histomorphological ADC growth patterns (lepidic, acinar, papillary, micropapillary and solid) and data from pre-operative assessment by computed tomography (CT) imaging of 174 resected pulmonary ADCs were analysed.Margin configuration as well as solidity/ground glass opacity of an ADC was associated with distinct histomorphological ADC growth patterns. Solid-predominant ADCs usually had smooth margins and were also solid in CT scans, while lepidic-predominant ADCs had no predominant margin pattern, were located in the periphery, showed a positive bronchogram and were frequently associated with solidity/ground glass opacity. In addition, nonspherical tumour growth was a negative predictor of overall and disease-specific patient survival.We defined CT morphological parameters that were associated with histomorphological growth patterns of pulmonary ADCs. These data may form the basis for the development of future prognostic algorithms in the palliative setting, which include an integrated evaluation of biopsy histomorphology and CT scan morphology of nonresectable pulmonary ADC.

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Section: Discussionmentioning

confidence: 99%

Correlation of radio- and histomorphological pattern of pulmonary adenocarcinoma

et al. 2012

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“…Literatürdeki çoğu seride benign lezyonların daha yüksek olduğu saptanmış, benign lezyonların %70-80'inin enfeksiyöz/enflamatuvar granülomlar, %10'unun hamartomlar, geri kalanların adenom, lipom, kondrom, leiyomiyom, fibrom gibi daha nadir hastalıklara bağlı olduğu bildirilmiştir. [7,8] Literatürde HME toraks tutulumunu araştıran geniş seriler bulunmamakta; genelde olgu sunumları şek-linde bildirimler bulunmaktadır. Cottalorda ve ark.…”

Section: Discussionunclassified

A case of hereditary multiple exostosis presenting as solitary pulmonary nodule

Doğan¹,

Cömert²,

Kıral³

et al. 2012

J Kartal TR

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“…For the distinction of benign and malignant lesions; location, diameter, calcification of the lesion, and the number of lesions are important [20]. Irregular and speculated lesions strongly suggest malignancy, whereas lesions with smooth, well-defined margins are more likely to be benign [16,[20][21][22][23]. The presence and pattern of calcification are strong indicators for benignancy [16,20,21,24].…”

Section: Discussionmentioning

confidence: 99%

“…Irregular and speculated lesions strongly suggest malignancy, whereas lesions with smooth, well-defined margins are more likely to be benign [16,[20][21][22][23]. The presence and pattern of calcification are strong indicators for benignancy [16,20,21,24]. Additionally, stability of the lesions for two years, and small size of the lesions (<2 -3, 5 mm) are other factors suggestive of benign disease [10,16,21,22,24,25].…”

Section: Discussionmentioning

confidence: 99%