The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron

Forrest, Michael; Wall, Mark J.; Press, Daniel A.; Feng, Jianfeng

doi:10.1371/journal.pone.0051169

Cited by 65 publications

(110 citation statements)

References 68 publications

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“…The model's dendrite correction factor: C d = 3.80 (Forrest et al, 2012). For smooth compartments, C m = 0.8 * C d μF/cm 2 .…”

Section: Methodsmentioning

confidence: 99%

Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs

Forrest

2014

Front. Comput. Neurosci.

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Without synaptic input, Purkinje neurons can spontaneously fire in a repeating trimodal pattern that consists of tonic spiking, bursting and quiescence. Climbing fiber input (CF) switches Purkinje neurons out of the trimodal firing pattern and toggles them between a tonic firing and a quiescent state, while setting the gain of their response to Parallel Fiber (PF) input. The basis to this transition is unclear. We investigate it using a biophysical Purkinje cell model under conditions of CF and PF input. The model can replicate these toggle and gain functions, dependent upon a novel account of intracellular calcium dynamics that we hypothesize to be applicable in real Purkinje cells.

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“…The model's dendrite correction factor: C d = 3.80 (Forrest et al, 2012). For smooth compartments, C m = 0.8 * C d μF/cm 2 .…”

Section: Methodsmentioning

confidence: 99%

Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs

Forrest

2014

Front. Comput. Neurosci.

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“…This striking complexity of PC firing is made possible by the expression of an array of calcium channels and calcium-activated potassium channels (Swensen and Bean, 2003;Foehring et al, 2009;Carter and Bean, 2011;Hosy et al, 2011;Forrest et al, 2012;Forrest, 2013). Most important among them are P/Q-type voltage-gated calcium channels (sustain spontaneous bursting and dendritic calcium spiking), and T-type voltage-gated calcium channels, small-conductance (SK) and large-conductance (BK) calcium-dependent potassium channels.…”

Section: Spinal Cerebellar Ataxiamentioning

confidence: 99%

From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases

Roselli

Caroni

2015

Neuron

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Neurodegenerative diseases (NDDs) involve years of gradual preclinical progression. It is widely anticipated that in order to be effective, treatments should target early stages of disease, but we lack conceptual frameworks to identify and treat early manifestations relevant to disease progression. Here we discuss evidence that a focus on physiological features of neuronal subpopulations most vulnerable to NDDs, and how those features are affected in disease, points to signaling pathways controlling excitation in selectively vulnerable neurons, and to mechanisms regulating calcium and energy homeostasis. These hypotheses could be tested in neuronal stress tests involving animal models or patient-derived iPS cells.

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“…The Na+ATPase, was confirmed to control the cell volume which is important for homeostasis of neuron (Nylander-Koski et al, 2005). Na + ATPase has specially role in neuron activity states, such as control and set the intrinsic activity mode of cerebellar Purkinje neurons (Forrest et al, 2012). Moreover, the plasma membrane Ca2+ATPaseare also important for the normal neuron function as it had been reported to regulating synaptic activity (Jensen et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Xinnaoning Tablet in Ischemic Stroke in Rat Model

Lv¹,

Xie²,

Feng³

et al. 2018

AJTCAM

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Background: Stroke has been considered as the second leading cause of death worldwide. The survivors of stroke experience different level of impair brain function. In China, Chinese traditional medicine had been widely accepted for stroke therapy and prevention. In this study, we developed Traditional Chinese Medicine based Xinnaoning (peace of heart and brain) Tablet and tested its protective role for ischemic stroke in rat model. Material and Methods: Male Wistar rats (n=60) with 12 weeks old and weight from 180 to 200 gram were randomly divided to five groups (n=12). For the groups with Xinaoning administration, the drug was administrated to rats once per day for 7 consecutive days. The blood clotting time and the thrombus wet weight was measured. Serum samples were collected from each rat for further Measurement of biochemical indicators. Results: Our results demonstrated that Xinnaoning tablet reduced lactate acid (LD) level and increased lactic acid dehydrogenase (LDH) in cerebral ischemia model as well as reduced the infarct size caused by stroke. Besides, evaluation of the level of different ATPases suggested Xinnaoning tablet could modulate ATPases activity and confer a protective role in brain. Moreover, analysis indicated Xinnaoning tablet have the anti-coagulation effect in vivo which may contribute to the protection of ischemia. Conclusion: Our findings suggest that Xinnaoning tablet may be a potential way for cerebral ischemia prevention.

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The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron

Cited by 65 publications

References 68 publications

Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs

Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs

From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases

Protective Role of Xinnaoning Tablet in Ischemic Stroke in Rat Model

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