The sodium leak channel complex is modulated by voltage and extracellular calcium

Chua, Han Chow; Wulf, Matthias; Weidling, Claudia; Rasmussen, L. P.; Pless, Stephan A.

doi:10.1101/740456

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…NALCN has been shown to control the resting membrane potential by regulating sodium leak conductance. Moreover, NALCN has been reviewed to play a key function in excitable tissues, such as neuronal excitability, circadian and respiration rhythms (Lu et al, 2007;Chua et al, 2020;Kschonsak et al, 2020). Neurological disorders are related to NALCN gain-of-function mutations (Bend et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

NALCN is a potential biomarker and therapeutic target in human cancers

Chang

et al. 2023

Front. Genet.

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Background: Sodium leak channel non-selective (NALCN), known as a voltage-independent Na+ channel, is increasingly considered to play vital roles in tumorigenesis and metastasis of human cancers. However, no comprehensive pan-cancer analysis of NALCN has been conducted. Our study aims to explore the potential diagnostic, prognostic and therapeutic value of NALCN in human cancers.Methods: Through comprehensive application of datasets from Human Protein Atlas (HPA), The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Enhanced Version of Tumor Immune Estimation Resource (TIMER2.0), Tumor and Immune System Interaction Database (TISIDB), The University of Alabama at Birmingham Cancer data analysis Portal (UALCAN), cBioPortal, GeneMANIA and Search Tool for the Retrieval of Interaction Gene/Proteins (STRING) databases, we explored the potential roles of NALCN in different cancers. The differential expression, prognostic implications, pathological stages and grades, molecular and immune subtypes, diagnostic accuracy, tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) genes, immune checkpoint genes, chemokine genes, major histocompatibility complex (MHC)-related genes, tumor-infiltrating immune cells (TIICs), promoter methylation, mutations, copy number alteration (CNA), and functional enrichment related to NALCN were analyzed.Results: Most cancers lowly expressed NALCN. Upregulated NALCN expression was associated with poor or better prognosis in different cancers. Moreover, NALCN was correlated with clinicopathological features in multiple cancers. NALCN showed high diagnostic accuracy in 5 caner types. NALCN is highly linked with immune-related biomarkers, immune-related genes and TIICs. Significant methylation changes and genetic alteration of NALCN can be observed in many cancers. Enrichment analysis showed that NALCN is closely related to multiple tumor-related signaling pathways.Conclusion: Our study revealed the vital involvement of NALCN in cancer. NALCN can be used as a prognostic biomarker for immune infiltration and clinical outcomes, and has potential diagnostic and therapeutic implications.

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Section: Introductionmentioning

confidence: 99%

NALCN is a potential biomarker and therapeutic target in human cancers

Chang

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

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The sodium leak channel complex is modulated by voltage and extracellular calcium

Cited by 1 publication

References 43 publications

NALCN is a potential biomarker and therapeutic target in human cancers

NALCN is a potential biomarker and therapeutic target in human cancers

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