The Sodium‐Calcium Exchange System

Baker, P. F.

doi:10.1002/9780470513347.ch6

Cited by 12 publications

(1 citation statement)

References 45 publications

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“…Furthermore it has also been reported that the plasma membrane of many cell types contains a carrier which catalyzed the exchange of ions [41] . Stimulation of both liver mitochondrial and microsomal ATPase by bromocriptine, in contrast to inhibition of both liver mitochondrial and microsomal ATPase by sulpiride which may increase liver intercellular Ca 2 ions through an exchange Na 2 /Ca 2 mechanism [41][42][43][44][45][46][47][48] . Furthermore, this result is in agreement with the findings that there is association between Ca 2+ transport and the concentration of Na + and K + , which has been demonstrated in vitro [49] and in vivo [50] .…”

Section: Discussionmentioning

confidence: 99%

Involvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 Receptors

Abu-Jayyab¹

2009

American J. of Pharmacology and Toxicology

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Problem statement: Our previous research has shown that mitochondrial ATPase may have a role in the action of dopaminergic D 2 receptors. It is therefore, thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the mitochondrial and microsomal ouabain sensitive and ouabain insensitive Na + /K + -ATPase in the liver of rats. Approach: In vivo treatment was carried out to study the effects of bromocriptine mesylate 10 mg kg −1 , sulpiride 10 mg kg −1 ; or bromocriptine mesylate 10 mg kg −1 + sulpiride 10 mg kg −1 , compared to a control group, in order to measure liver Na + /K + -ATPase activity. The drugs were injected intraperitoneally daily for 14 days. Mitochondrial and microsomal fractions were obtained by the methods of Schwartz. Results: Pretreatment of rats with both bromocriptine and sulpiride given simultaneously resulted in complete abolition of stimulation caused by bromocriptine and inhibition that resulted from sulpiride on mitochondrial as well as microsomal ATPase activities. Conclusion: This study indicated that the in vivo administration of dopaminergic agonist and antagonist drugs result in a significant alteration not only in the mitochondrial ATPase enzyme activity but also in the microsomal ATPase enzyme activity. Therefore, it is quite possible that ATPase of the tow fractions play important physiological as well as pathological roles in the mechanism of action of dopaminergic receptors.

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Section: Discussionmentioning

confidence: 99%

Involvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 Receptors

Abu-Jayyab¹

2009

American J. of Pharmacology and Toxicology

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Does potassium induce the release of nitric oxide in the rabbit corpus cavernosum?

Saito

Ohmura²,

Kondo³

1998

Urological Research

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We investigated the effects of increases in the extracellular potassium concentration on the function of the rabbit corpus cavernosum. The resting tissue tension increased as the potassium concentration was increased from 4.7 mM to 20 mM or 30 mM. The maximum contraction induced by 200 microM phenylephrine was significantly decreased in the presence of 30 mM potassium compared with 4.7 mM potassium. After precontraction was induced with 200 microM phenylephrine, the magnitude of field-stimulated relaxation increased significantly as the potassium concentration was increased from 4.7 mM to 10 or 20 mM, but was almost completely abolished at 30 mM potassium. There was no difference in the suppressive effect of L-NAME on field-stimulated relaxation between specimens treated with 4.7 mM or 20 mM potassium. ATP- and bethanechol-induced relaxation was not affected by increases in the extracellular potassium concentration. A high-dose potassium solution (124 mM) induced contraction of the corpus cavernosum. In tissue precontracted with phenylephrine, a high-dose potassium solution that contained phenylephrine induced relaxation of corpus cavernosum; this relaxation was completely suppressed by L-NAME. These findings suggest that small increases in the extracellular potassium concentration increase field-stimulated relaxation of the corpus cavernosum and that this relaxation is not related to the effects of nitric oxide. Relaxation induced by high-dose potassium in tissue precontracted with phenylephrine is probably the result of release of nitric oxide.

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Numerical approximations of sodium-calcium exchange

Hilgemann

1988

Progress in Biophysics and Molecular Biology

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The Sodium‐Calcium Exchange System

Cited by 12 publications

References 45 publications

Involvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 Receptors

Involvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 Receptors

Does potassium induce the release of nitric oxide in the rabbit corpus cavernosum?

Numerical approximations of sodium-calcium exchange

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