volume 192, issue 3, P1231-1240 2014
DOI: 10.4049/jimmunol.1300720
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Sara Trabanelli, Darina Očadlíková, Marilena Ciciarello, Valentina Salvestrini, Mariangela Lecciso, Camilla Jandus, Richard Metz, Cecilia Evangelisti, Lisa Laury-Kleintop, Pedro Romero, George C. Prendergast, Antonio Curti, Roberto M. Lemoli

Abstract: Dendritic cells (DC) are professional antigen-presenting cells that have a role in the initiation of adaptive immune responses and tolerance. Among the tolerogenic mechanisms, the expression of the enzyme indoleamine 2,3-dioxygenase (IDO1) represents an effective tool to generate T regulatory cells (Treg). In humans, different DC subsets express IDO1, but less is known about the IDO1-related enzyme, IDO2. Here, we found a different pattern of expression and regulation between IDO1 and IDO2 in human circulatin…

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