The SOCS and STAT from JAK/STAT signaling pathway of kuruma shrimp Marsupenaeus japonicus: Molecular cloning, characterization and expression analysis

Okugawa, S.; Mekata, Tohru; Inada, Mari; Kihara, Keisuke; Shiki, Ayumi; Каннабиран, Кришнан; Kono, Tomoya; Sakai, Masahiro; Yoshida, Terutoyo; Itami, Toshiaki; Sudhakaran, R.

doi:10.1016/j.mcp.2012.08.003

Cited by 39 publications

(26 citation statements)

References 29 publications

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“…In crustacean, several STAT proteins have been isolated from L. vannamei [17], F. chinensis [18], P. monodon [19], M. japonicas [20] and A. franciscana [16]. However, there is only a Janus Kinase from A. franciscana functionally identified in crustacea.…”

Section: Discussionmentioning

confidence: 99%

“…In crustacean, the Artemia franciscana JAK is the only JAK gene that has been reported [16]. But several STAT genes were studied in other species such as A. franciscana [16], L. vannamei [17], Fenneropenaeus chinensis [18], Penaeus monodon [19] and Marsupenaeus japonicas [20]. In this study, a JAK gene was cloned from L. vannamei (named as LvJAK), and its mRNA expression and potential functions were examined during white spot syndrome virus (WSSV) infection.…”

Section: Introductionmentioning

confidence: 99%

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A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

Song

Zhang

Wang

et al. 2015

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

Song

Zhang

Wang

et al. 2015

Fish & Shellfish Immunology

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“…In marine invertebrates, STAT genes have been identified from black tiger shrimp Penaeus monodon and kuruma shrimp Marsupenaeus japonicus, and displayed induced expression profiles after WSSV or peptidoglycan exposure [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…The SH2 domain in SOCS family compete with STATs-SH2 domain or hinder the STAT binding sites of receptors, inhibiting STATs activation, especially in the case of STAT5 [18]. Previous studies had shown that microorganisms can induce different SOCS proteins [19,20], but only few reports have been characterized the relationship between JAK/STAT and SOCS in invertebrate after immunostimulation [11,21]. In vertebrate, SOCS proteins have other functions.…”

Section: Introductionmentioning

confidence: 99%

“…Identification of novel immune-related genes involved in specific signaling pathways will give new insights into the immune defense mechanisms and control the disease outbreaks in this specie, particularly the JAK/STAT signal transduction pathway, which plays a critical role in host defence against bacterial infections [11,27]. In current study, we will firstly give insights into the structural evolution and functional characteristics of STAT, FOXP, and SOCS genes in A. japonicus.…”

Section: Introductionmentioning

confidence: 99%

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Three members in JAK/STAT signal pathway from the sea cucumber Apostichopus japonicus: Molecular cloning, characterization and function analysis

Shao

Zhang

et al. 2015

Fish & Shellfish Immunology

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Isalo scorpion cytotoxic peptide‐strengthened immune function through the JAKs/STATs signaling pathway of the immune organ of grass carp (Ctenopharyngodon idella) challenged with Aeromonas hydrophila

He,

Hu,

Zhou

et al. 2024

Animal Research and One Health

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To investigate the impact of Isalo scorpion cytotoxic peptide (IsCT) on the immune function of immune organ (head kidney, spleen, and skin) of grass carp (Ctenopharyngodon idella), 540 fish (136.88 ± 0.72 g) were supplied with a different amount of IsCT (0, 0.6, 1.2, 1.8, 2.4, and 3.0 mg/kg diet) through a period of 60 days. Afterward, 24 fish were randomly selected from each group and were inoculated with Aeromonas hydrophila for a period of 6 days. Our findings suggested that appropriate IsCT complementation: (1) attenuated skin morbidity and histopathological structural changes in the head kidney and spleen (p < 0.05), which ensured the structural integrity of the immune organs; (2) increased the activity and expression of immune substances (p < 0.05), which in turn increased the function of the immune organs, promoting immune responses; (3) through the regulation of the Janus kinase/signal transducers and activators of transcription (JAKs/STATs) signaling pathway, the mRNA expression of anti‐inflammatory cytokines increased and the mRNA expression of pro‐inflammatory cytokines decreased, which in turn increased the function of the immune organs, reducing the inflammatory response (p < 0.05). However, the addition of IsCT did not affect the expression of IL‐12p35, STAT2, and STAT3a in the immune organ. Ultimately, this study provided evidence that IsCT enhanced immune function via the JAKs/STATs signaling pathway in the immune organ in grass carp after challenged with Aeromonas hydrophila.

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The SOCS and STAT from JAK/STAT signaling pathway of kuruma shrimp Marsupenaeus japonicus: Molecular cloning, characterization and expression analysis

Cited by 39 publications

References 29 publications

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

Three members in JAK/STAT signal pathway from the sea cucumber Apostichopus japonicus: Molecular cloning, characterization and function analysis

Isalo scorpion cytotoxic peptide‐strengthened immune function through the JAKs/STATs signaling pathway of the immune organ of grass carp (Ctenopharyngodon idella) challenged with Aeromonas hydrophila

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