The SOCS-1 -1478CA/del Polymorphism is not Associated with Colorectal Cancer or Age at Onset in Turkish Subjects

Abstract

Background: Suppressor of cytokine signaling (SOCS)-1 acts as a key regulator of many cytokine signaling pathways and its abnormal expression has been identified in several human malignancies, suggesting potential roles in carcinogenesis. The aim of this study was to investigate any association between the functional SOCS-1 -1478CA>del polymorphism and colorectal cancer (CC) as well as age at onset in a Turkish clinical sample. Materials and Methods: A total of 122 subjects were enrolled in this case-control study (70 CC cases and 52 controls). The SOCS-1 -1478CA>del polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The odds ratio of the del allele for CC relative to the CA allele was not significantly different between the groups (OR=0.71, 95% CI=0.41-1.22, p=0.27). This result did not change after adjustment for age and sex on multivariable regression analysis (OR=0.84, 95% CI=0.59-1.34, p=0.53). When the SOCS-1 -1478CA>del polymorphism was analyzed among CC patients in relation to the age at disease onset, we found no significant differences between subjects with the del/del, CA/del, and CA/CA genotypes. Conclusions: The results of our study did not point towards a major role of the SOCS-1 -1478CA>del polymorphism in the pathogenesis of CC in Turkish subjects.

SOCS1 is a critical checkpoint in immune homeostasis, inflammation and tumor immunity

“…A polymorphism in the SOCS1 promoter region (-1478 CA>del) has been reported to increase SOCS1 expression in atopic asthma (127), and has been associated with breast and gastric cancer, as well as with a poorer outcome in colon cancer (128)(129)(130)(131). The effect of this polymorphism remains unclear, although it does not appear to be linked to tumor suppression.…”

The genetic effect and molecular function of the SOCS5 in the prognosis of esophageal squamous cell carcinoma

“…Studies of the genetic polymorphisms in the SOCS family of genes in solid tumor are not extensive. Single nucleotide polymorphisms (SNPs) of the SOCS1 and SOCS3 genes have been analyzed in colorectal cancer patients 23 - 24 . However, no association of these SNPs and cancer development has been found.…”