The socially-isolated rat as a model for anxiety

Parker, Vivienne; Morinan, Alun

doi:10.1016/0028-3908(86)90224-8

Cited by 98 publications

(45 citation statements)

References 7 publications

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“…Anxiogenic on elevated plus-maze (Parker and Morinan, 1986;Weiss et al, 2004;Wright et al, 1991a,b) Hypo-neophagia (Parker and Morinan, 1986), reduced cage escape latency (Parker and Morinan, 1986) Depression Little change in immobility or struggling time in the Porsolt forced swim test in mice (Hilakivi et al, 1989) or rats (Hall et al, 1998a(Hall et al, , 2001 Desipramine more effective in isolates (Wongwitdecha et al, 2006) Gentsch et al, 1982b;Heidbreder et al, 2000;Hughes and Syme, 1972;Phillips et al, 1994b;Silva-Gomez et al, 2003;Syme, 1973) due to less time spent resting. Careful analysis of this behaviour with photocells or computerised tracking shows that the response is strain dependent.…”

Section: Anxietymentioning

confidence: 96%

“…Some groups have reported modest increases in anxiety-related behaviours on the elevated plus maze in isolation-reared rats (Bickerdike et al, 1993;Hellemans et al, 2004;Parker and Morinan, 1986;Wright et al, 1991b) while others have found no effect using a similar protocol and strain of rats (Fone et al, 1996). Similarly following 90 days isolation of Long-Evans rats there was no effect on the behavioural profile in the black/white box (Hellemans et al, 2004) and although these workers reported an anxiogenic-like profile in the elevated plus maze test an error in data collection meant that some control groups were not reported in their study.…”

Section: Anxiety-like Behaviourmentioning

confidence: 99%

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Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Fone

Porkess

2008

Neuroscience & Biobehavioral Reviews

768

590

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Section: Anxietymentioning

confidence: 96%

Section: Anxiety-like Behaviourmentioning

confidence: 99%

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Fone

Porkess

2008

Neuroscience & Biobehavioral Reviews

768

590

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“…In the literature, it has been sufficiently demonstrated that IR conditions affect the raphe 5-HT system [21], thus causing specific behavioural disturbances [22,23]. However, the literature also indicates that the molecular layers of the hippocampal DG may be spared from an underdeveloped 5-HT structure and function resulting from IR conditions [32].…”

Section: Discussionmentioning

confidence: 99%

“…Isolated rearing and housing of rats has been found to decrease the 5-HT release and turnover in hippocampal terminal fields [19] in connection with the perturbation of postsynaptic 5-HT processes [20; for a recent review, see ref. 21], thus reducing serotoninergic functions as expressed in an animal model of anxiety [22] and depression [23]. With regard to the application of substituted amphetamines, a complex sequence of events induces neurotoxicity by the increase in free radicals in aminergic terminals [for a recent review, see ref.…”

Section: Introductionmentioning

confidence: 99%

Differential Influence of Rearing Conditions and Methamphetamine on Serotonin Fibre Maturation in the Dentate Gyrus of Gerbils <i>(Meriones unguiculatus)</i>

Busche¹,

Neddens²,

Dinter³

et al. 2002

Dev Neurosci

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Environmental experience and drugs are two parameters that affect the maturation of neurotransmitter systems. The influence of impoverished rearing (IR) versus enriched rearing (ER) was compared in conjunction with postnatal methamphetamine (MA) treatment. The densities of immunostained 5-HT fibres were quantified in septal and temporal regions of the hippocampal dentate gyrus (DG) in young adult gerbils. In the IR group, 5-HT fibre densities were significantly increased in the molecular, granular and polymorphic layers of the DG in the temporal plane. After postnatal MA treatment, the 5-HT fibre density in the ER group reached a level equivalent to that of the IR group in nearly all respects. Under IR conditions, the pharmacological intervention significantly increased the maturation of fibre densities in septal layers only in the right hemisphere with no significant alterations in the left hemisphere and in temporal regions of either hemisphere. According to our previous studies on hippocampal neurogenesis, adaptations of 5-HT fibre densities partly proved to be positively correlated to cell proliferation rates for each of the specific conditions. Thus, the induced MA sensitivity, caused by pharmacological intervention at day 14, was manifested as direct interaction of 5-HT fibre maturation and cell proliferation in dependence of environmental factors. Both IR and MA together give us a better understanding of raphe-hippocampal plasticity and offer new perspectives for pharmacological studies on the 5-HT participation in mental disorders.

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“…Perhaps missing, though, is investigation of social stressors as well as a comparison of acute and chronic stress exposure. Responses to social and non-social stressors do vary (Branchi et al, 2013), and social stressors, in particular social isolation housing, have been extensively studied in the prairie vole (Grippo et al, 2007b(Grippo et al, ,c, 2009Pan et al, 2009;Ruscio et al, 2007) as well as the rat (Malkesman et al, 2006;Parker and Morinan, 1986;Weiss et al, 2004;Yorgason et al, 2013). Similarly, HPA function varies between acute and chronic stress exposure (see Lightman, 2008 for review).…”

Section: Stress Responsivenessmentioning

confidence: 99%

Intergenerational transmission of sociality: the role of parents in shaping social behavior in monogamous and non-monogamous species

Perkeybile

Bales

2017

Journal of Experimental Biology

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Social bonds are necessary for many mammals to survive and reproduce successfully. These bonds (i.e. pair-bonds, friendships, filial bonds) are characterized by different periods of development, longevity and strength. Socially monogamous species display certain behaviors not seen in many other mammals, such as adult pairbonding and male parenting. In our studies of prairie voles (Microtus ochrogaster) and titi monkeys (Callicebus cupreus), we have examined the neurohormonal basis of these bonds. Here, we discuss the evidence from voles that aspects of adolescent and adult social behavior are shaped by early experience, including changes to sensory systems and connections, neuropeptide systems such as oxytocin and vasopressin, and alterations in stress responses. We will compare this with what is known about these processes during development and adulthood in other mammalian species, both monogamous and non-monogamous, and how our current knowledge in voles can be used to understand the development of and variation in social bonds. Humans are endlessly fascinated by the variety of social relationships and family types displayed by animal species, including our own. Social relationships can be characterized by directionality (either uni-or bi-directional), longevity, developmental epoch (infant, juvenile or adult) and strength. Research on the neurobiology of social bonds in animals has focused primarily on 'socially monogamous' species, because of their long-term, strong adult affiliative bonds. In this Review, we attempt to understand how the ability and propensity to form these bonds (or lack thereof), as well as the display of social behaviors more generally, are transmitted both genomically and non-genomically via variation in parenting in monogamous and non-monogamous species.

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The socially-isolated rat as a model for anxiety

Cited by 98 publications

References 7 publications

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Differential Influence of Rearing Conditions and Methamphetamine on Serotonin Fibre Maturation in the Dentate Gyrus of Gerbils <i>(Meriones unguiculatus)</i>

Intergenerational transmission of sociality: the role of parents in shaping social behavior in monogamous and non-monogamous species

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