The social network: Impact of host and microbial interactions on bacterial antibiotic tolerance and persistence

Rocha-Granados, Maria C.; Zenick, Blesing; Englander, Hanna E.; Mok, Wendy W. K.

doi:10.1016/j.cellsig.2020.109750

Cited by 17 publications

(14 citation statements)

References 159 publications

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“…The misuse of antibiotics, as well as inappropriate prescription and overuse, has led to strong selective pressure, resulting in the survival and wide distribution of drug-resistant pathogens that threaten the public health system globally (Barbosa and Levy, 2000;Ventola, 2015). Acquired drug resistance to antimicrobial agents has been a widely recognized problem (Tenover, 2001;Spellberg et al, 2004;Wall, 2019;Rocha-Granados et al, 2020). Bacteria can respond rapidly to environmental changes owing to their short growth cycles, which enable them to evolve and adapt rapidly and survive under unfavorable conditions (Clatworthy et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Iodine-Containing Nano-Micelles, FS-1, on Antibiotic Resistance, Gene Expression and Epigenetic Modifications in the Genome of Multidrug Resistant MRSA Strain Staphylococcus aureus ATCC BAA-39

Reva

Korotetskiy²,

Joubert

et al. 2020

Front. Microbiol.

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Section: Introductionmentioning

confidence: 99%

The Effect of Iodine-Containing Nano-Micelles, FS-1, on Antibiotic Resistance, Gene Expression and Epigenetic Modifications in the Genome of Multidrug Resistant MRSA Strain Staphylococcus aureus ATCC BAA-39

Reva

Korotetskiy²,

Joubert

et al. 2020

Front. Microbiol.

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“…Previous studies have reported the same phenomenon in sewage sludge-applied soils (Chen et al, 2016), reclaimed water-applied soils (Wang et al, 2014), swine farms (Zhu et al, 2013), and chicken manure or cattle manure-applied soils (Wang et al, 2020a). Efflux pumps are major players in both intrinsic and acquired resistance to drugs currently in use for the treatment of infectious diseases (Hernando-Amado et al, 2016), which are either chromosomal or plasmid-encoded (Rocha-Granados et al, 2020), and deserves more attention because they are often associated with the multidrug antibiotic resistance (Wang et al, 2020a).…”

Section: Different Manures Did Not Significantly Change the Antibiotic Resistance Gene Profiles In Alkaline Soilmentioning

confidence: 80%

Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years

et al. 2021

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Animal manure is a reservoir of antibiotic resistance genes (ARGs), and direct application of the manure will lead to spread of ARGs in farmland. Here, we explored the impacts of chicken manure and heat-treated chicken manure on the patterns of soil resistome after 3 years’ application, with mushroom residues set as the plant-derived organic manure treatment. A total of 262 ARG subtypes were detected in chicken manure using high-throughput qPCR, and heat treatment can effectively remove 50 types of ARGs. Although ARG subtypes and abundance were both higher in chicken manure, there was no significant difference in the ARG profiles and total ARG abundance among three manure-treated soils. Soil bacteria community compositions were significantly different among manure-treated soils, but they were not significantly correlated with soil ARG profiles. Fast expectation–maximization microbial source tracking (FEAST) was used for quantifying the contributions of the potential sources to microbial taxa and ARGs in manure-fertilized soil. Results revealed that only 0.2% of the chicken manure-derived bacterial communities survived in soil, and intrinsic ARGs were the largest contributor of soil ARGs (95.8–99.7%); ARGs from chicken manure only contributed 0.4%. The total ARG abundance in the heat-treated chicken manure-amended soils was similar to that in the mushroom residue-treated soils, while it was 1.41 times higher in chicken manure-treated soils. Thus, heat treatment of chicken manure may efficiently reduce ARGs introduced into soil and decrease the risk of dissemination of ARGs.

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“…The presence of metabolites related to the degradation of natural compounds in these treatments is characterized by the non-specific response of bacteria and is related to a stress-mediated condition. This is an important point for tolerance and subsequent exposure to antimicrobial compounds ( Rocha-Granados et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Untargeted Metabolomics Approach of Cross-Adaptation in Salmonella Enterica Induced by Major Compounds of Essential Oils

et al. 2022

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Cross-adaptation phenomena in bacterial populations, induced by sublethal doses of antibacterial solutions, are a major problem in the field of food safety. In this regard, essential oils and their major compounds appear as an effective alternative to common sanitizers in food industry environments. The present study aimed to evaluate the untargeted metabolomics perturbations of Salmonella enterica serovar Enteritidis that has been previously exposed to the sublethal doses of the major components of essential oils: cinnamaldehyde, citral, and linalool (CIN, CIT, and LIN, respectively). Cinnamaldehyde appeared to be the most efficient compound in the assays evaluating the inhibitory effects [0.06% (v/v) as MBC]. Also, preliminary tests exhibited a phenotype of adaptation in planktonic and sessile cells of S. Enteritidis when exposed to sublethal doses of linalool, resulting in tolerance to previously lethal concentrations of citral. A metabolomics approach on S. Enteritidis provided an important insight into the phenomenon of cross-adaptation induced by sublethal doses of major compounds of some essential oils. In addition, according to the results obtained, when single molecules were used, many pathways may be involved in bacterial tolerance, which could be different from the findings revealed in previous studies regarding the use of phytocomplex of essential oils. Orthogonal projection to latent structures (OPLS) proved to be an interesting predictive model to demonstrate the adaptation events in pathogenic bacteria because of the global engagement to prevent and control foodborne outbreaks.

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The social network: Impact of host and microbial interactions on bacterial antibiotic tolerance and persistence

Cited by 17 publications

References 159 publications

The Effect of Iodine-Containing Nano-Micelles, FS-1, on Antibiotic Resistance, Gene Expression and Epigenetic Modifications in the Genome of Multidrug Resistant MRSA Strain Staphylococcus aureus ATCC BAA-39

The Effect of Iodine-Containing Nano-Micelles, FS-1, on Antibiotic Resistance, Gene Expression and Epigenetic Modifications in the Genome of Multidrug Resistant MRSA Strain Staphylococcus aureus ATCC BAA-39

Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years

Untargeted Metabolomics Approach of Cross-Adaptation in Salmonella Enterica Induced by Major Compounds of Essential Oils

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