The Social Impact of Suspected Adverse Drug Reactions: An analysis of the Canada Vigilance Spontaneous Reporting Database

Castillon, Genaro; Salvo, Francesco; Moride, Yola

doi:10.1007/s40264-018-0713-8

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Furthermore, these authors also indicate that AMR have a direct social impact, i.e., they directly affect people's lives. For this reason, Castillon et al (2019) suggest that social dimensions such as social and family functioning, psychological functioning, functioning related to daily life, and functioning at work or school should be included and assessed in AMR reporting. This gives an idea of the importance of the social aspects in pharmacovigilance.…”

Section: The Social Importance Of Pharmacovigilancementioning

confidence: 99%

Socio-historical analysis of the social importance of pharmacovigilance

2022

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Pharmacovigilance is a scientific discipline that has changed a lot in recent years and is of great social importance. The case of the so-called sulfonamide elixir showed society the importance of this discipline. Since then, pharmacovigilance has evolved into a scientific discipline with a strong social character. In this paper, a historical review is made of several paradigmatic examples of this discipline to reflect on what pharmacovigilance could be like finally. We conclude that this discipline could be more closely related to other areas of the social sciences, which would help to promote a more democratic social environment taking into account the needs of individuals and social groups.

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Section: The Social Importance Of Pharmacovigilancementioning

confidence: 99%

Socio-historical analysis of the social importance of pharmacovigilance

2022

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“…Nevertheless, conventional evaluations frequently fall short in encompassing neuropsychiatric symptoms, altered behavior patterns, financial hardships, and legal entanglements 23 , failing to capture the full spectrum of these disorders. This underscores the crucial need for an integrative approach, considering the perspectives of both patients and caregivers and acknowledging the complex interconnections between symptoms 24 .…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, conventional evaluations focus on simple drug – physical adverse reaction associations, and often ignore neuropsychiatric symptoms, altered behavior patterns, financial hardships, and legal entanglements as emerging from drug-induced impulsivity [23], thus failing to capture the complex network of consequences of its manifestation. This underscores the crucial need for an integrative approach that consider the perspectives of both patients and caregivers and acknowledges the complex interconnections between symptoms [24], including identifying subsyndromes and exacerbating events.…”

Section: Introductionmentioning

confidence: 99%

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Unveiling the Burden of Drug-Induced Impulsivity: A Network Analysis of the FDA Adverse Event Reporting System

Fusaroli,

Polizzi,

Menestrina

et al. 2023

Preprint

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IntroductionAdverse drug reactions significantly impact patients’ lives, yet their influence is often underestimated in treatment decisions and monitoring. Impulsivity induced by dopaminergic agents can lead to impaired social functioning and quality of life.AimThis study assesses impulsivity burdens from pramipexole and aripiprazole, pinpointing key symptoms for targeted mitigation.MethodLeveraging data from the FDA Adverse Event Reporting System (January 2004 - March 2022), we employed the Information Component to identify the syndrome of signs and symptoms disproportionately co-reported with drug-induced impulsivity. Using composite network analyses (PPMI, Ising,ϕ) we characterized clusters of co-reported events (i.e., subsyndromes). Finally, we assessed the secondary impact of drug-induced impulsivity modeling our dataset as a chain of directed connections (Bayesian network).ResultsThe drug-induced impulsivity syndrome (respectively 56 and 107 events in pramipexole and aripiprazole recipients), primarily encompassed psychiatric, social, and metabolic events, segregated into subsyndromes such as delusional jealousy and dopamine dysregulation syndromes among pramipexole recipients, and obesity-hypoventilation syndrome and social issues among aripiprazole recipients. Anxiety and economic problems emerged as pivotal nodes in the exacerbation of the syndromes.ConclusionDrug-induced impulsivity places a substantial burden on patients and their families, with manifestations shaped by the underlying disease. Network approaches, exploring intricate symptom connections and identifying pivotal symptoms, complement traditional techniques and clinical judgment, providing a foundation for informed prescription and targeted interventions to alleviate the burden of adverse drug reactions.

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Advances in Methods and Techniques in Pharmacovigilance for Herbal and Traditional Medicines and Other Natural Health Products

Barnes

2022

Pharmacovigilance for Herbal and Traditional Medicines

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The Social Impact of Suspected Adverse Drug Reactions: An analysis of the Canada Vigilance Spontaneous Reporting Database

Abstract: Findings from this study support the consideration of direct social issues as ADRs in the detection of drug safety signals.

Cited by 7 publications

References 11 publications

Socio-historical analysis of the social importance of pharmacovigilance

Socio-historical analysis of the social importance of pharmacovigilance

Unveiling the Burden of Drug-Induced Impulsivity: A Network Analysis of the FDA Adverse Event Reporting System

Advances in Methods and Techniques in Pharmacovigilance for Herbal and Traditional Medicines and Other Natural Health Products

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