“…Although cognitive decline is linked with aging, the rate of this decline in aging is highly variable (Fillit et al 2002;Park, O'Connell, & Thomson, 2003) and can depend on a variety of individual differences, including exaggerated inflammatory responses (Tegeler et al, 2016;Tuenissen et al, 2003;Yaffe et al, 2003) and elevated body mass (Memel, Bourassa, Woolverton, & Sbarra, 2016), as well as a host of psychosocial and health behavior variables (e.g., social engagement, physical health, physical activity, and depression (Bourassa, Memel, Woolverton, & Sbarra, 2015). With the rate of adults 65 years and older rising relative to the overall population in almost all developed countries (Restrepo & Rozental, 1994), understanding what risk factors are associated with cognitive decline is essential for developing interventions to promote successful aging. To explore one potential pathway that might explain risk for cognitive decline among aging adults, we examined the associations among body mass, inflammation, and change in cognition over 6 years in a nationally representative sample of older adults.…”