The Social Effects of Native Title  : Recognition, Translation, Coexistence

Morphy, Frances; R., Benjamin Smith

doi:10.26530/oapen_459535

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…In addition, some protein targets contain multiple small-molecule binding sites, which may allow chemically diverse drugs to bind [35][36][37] . For example, it has been shown that protein kinase inhibitors such as, imatinib and nilotinib, are also able to target smoothened receptor of the Hedgehog pathway; celecoxib targets prostaglandin G/H synthase 2, carbonic anhydrases, and several nuclear receptors 38,39 .…”

Section: Discussionmentioning

confidence: 99%

Extended Multitarget Pharmacology of Anticancer Drugs

Shi

Khan

Abagyan

2019

J. Chem. Inf. Model.

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Multi-target pharmacology of small molecule cancer drugs significantly contributes to their mechanism of action, side effects, emergence of drug resistance, and opens ways to repurpose, combine or customize drug therapy. In most cases the set of targets affected at therapeutic concentrations is not fully characterized and/or the interaction efficacy values are not accurately quantified. We collected information about multiple targets for each cancer drug along with their experimental effective concentrations or binding activities from multiple sources. All multi-target activity values for each drug then were used to build two proximity network pharmacology maps of anti-cancer drugs and targets of those drugs, respectively. Together with the network map, we showed that the majority of the cancer drugs had substantial multi-target pharmacology based on our current knowledge. In addition, most of the cancer drugs simultaneously affect macromolecular targets from different classes and types. The target subset can further be accentuated and personalized by patient sample specific expression data. The network maps of cancer drugs and targets, as well as all quantified activity data were integrated into a freely available database, CancerDrugMap (http://ruben.ucsd.edu/dnet/maps/drugnet.html). The identified multi-target pharmacology of cancer drugs is essential for improving the efficacy of individually prescribed drugs and drug combinations and minimization of adverse effects.

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Section: Discussionmentioning

confidence: 99%

Extended Multitarget Pharmacology of Anticancer Drugs

Shi

Khan

Abagyan

2019

J. Chem. Inf. Model.

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(Im)mobility: regional population structures in Aboriginal Australia

Morphy¹

2010

Aust J Social Issues

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The socio-cultural factors underlying contemporary Aboriginal settlement and mobility patterns are invisible to the categorisations that underpin both demographic modelling and policy that relies on that modelling. Taking the Yolngu people of north east Arnhem Land as a case study, this paper elaborates an anchored network model consisting of three tiers-an ontologically prior ancestral geography, with its associated contemporary settlements, to which kin-based networks are anchored by nodal individuals. While the content of each tier may vary across the continent, this model can potentially be applied wherever Aboriginal Australians continue to live in kin-based social universes. It is argued that constructing a 'recognition space' between conventional demographic categories and Aboriginal categorisations of their socio-spatial universes would lead to more informed policy-making on the part of government. Such policies would take account of the aspirations of Aboriginal people rather than imposing upon them the state's aspirations for them.

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The Magic of Narrative in the Emplotment of State‐Subject Relations: Who's Telling Whose Story in the Native Title Process in Australia?

Pilbrow

2013

Oceania

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Since 1992 Australian Aboriginal communities have been engaged in a complex and fraught legal process for the recognition of their traditional rights to country (‘native title’). In this article I argue that it is theoretically and critically illuminating to investigate the broader ‘meaning effects’ of the native title determination process on the subjective experience of the state in Australia. The article demonstrates this through examining the narrative effects of certain discursive moments through which identities get objectified. Through examining such moments in the discourse and practice of native title from the perspective of a participant‐observer, I seek to advance our theoretical understanding of how the narrative properties of speech (or other performative behaviours) in specific contexts structure the subjective experience of the state.

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The Social Effects of Native Title : Recognition, Translation, Coexistence

Cited by 8 publications

References 17 publications

Extended Multitarget Pharmacology of Anticancer Drugs

Extended Multitarget Pharmacology of Anticancer Drugs

(Im)mobility: regional population structures in Aboriginal Australia

The Magic of Narrative in the Emplotment of State‐Subject Relations: Who's Telling Whose Story in the Native Title Process in Australia?

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