The SNPs of Melanocortin 4 Receptor (&lt;i&gt;MC4R&lt;/i&gt;) Associated with Body Weight in Beagle Dogs

Zeng, Ruixia; Zhang, Yibo

doi:10.1538/expanim.63.73

Cited by 22 publications

(23 citation statements)

References 19 publications

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“…Seong et al (2012) reported that two "silent" SNPs (g.927C>T and g.1786C>T) in the MC4R gene in Korean cattle significantly influenced marbling score and back fat, respectively. Similar results have also been reported in dogs (g.895C>T) (Zeng et al, 2014). Szyndler-Nędza et al (2013) reported that the SNP g.1426G>A in MC4R significantly affects the fat and solid content of colostrum in dam-line pigs.…”

Section: Discussionsupporting

confidence: 85%

Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes

Tx¹,

Cy²,

Mq³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Melanocortin-4 receptor (MC4R) is associated with feed intake, growth, fatness, and carcass composition in many domestic animals. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Eight SNPs were identified by direct polymerase chain reaction sequencing of samples from 18 buffaloes. SNPs were then genotyped using the matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) method in 332 buffaloes. Two of eight SNPs were not in HardyWeinberg equilibrium. Based on the SNP data, seven haplotypes were constructed. Three SNPs H1 (AGT), H2 (GAT), and H3 (GAC) accounted for 93.0% of the total individuals. Statistical analysis indicated that the SNP g.1104C>T was significantly associated with milk yield, protein, and fat percentage (P < 0.05). In conclusion, these results provide evidence that polymorphisms in the buffalo MC4R gene are associated with milk production traits and might be potential biomarkers for water buffalo breeding.

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Section: Discussionsupporting

confidence: 85%

Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes

Tx¹,

Cy²,

Mq³

et al. 2016

Genet. Mol. Res.

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“…The genotype of MC4R gene based on single nucleotide polymorphism has also been reported as genetic marker for body weight in female Beagle dogs (Zheng et al, 2014), sexual desire behavior, feed intake and finishing weight in rabbit (Fontanesi et al, 2013;El-Sabrout, 2017;El-Sabrout and Soliman, 2017), egg production in Langsan chicken (Yan et al, 2013), feed intake, body weight and ADG in yak (Cai et al, 2015), back fat thickness and marbling score in Korean cattle (Seong et al, 2012), birth body length in Kebumen cattle (Maharani et al, 2018), ADG, loin-eye area and meat quality in sheep (Zou et al, 2014) and milk production in buffalo (Deng et al, 2016). In the previous study, genetics analysis (SNPs detection, amino acid change, restriction enzyme mapping and phylogenetic tree) of MC4R gene were reported in Bligon goat (Latifah et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Association of Melanocortin 4 Receptor gene polymorphism with growth traits in Bligon goat

Latifah

Maharani

Kustantinah

et al. 2018

J. Indonesian Trop. Anim. Agric.

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Melanocortin 4 receptor gene is a potential marker gene for growth performance in ruminant and non-ruminant animals. The objective of this study was to perform allele and genotype frequencies, and association of melanocortin 4 receptor with growth traits in Bligon goat. Seventy seven blood samples were collected and DNA isolated successfully. One pair primers were used for PCR of MC4R gene (F: 5’-TCGGGCGTCTTGTTCATCAT-3’ and R: 5’-CAAGACTGGGCACTGCTTCA-3’). Two SNPs (g.998A/G and g.1079C/T) were identified in exon of Bligon MC4R by DNA sequencing and PCR-RFLP. The SNP g.998A/G identified amino acid change from isoleucine to methionine (I-M), while the SNP g.1079C/T was synonymous polymorphism. Based on relationship analysis between Genotype of MC4R gene (SNP g.998A/G) and growth traits indicated that GG genotype was lowest in weaning weight (WW; AA=13.0±1.7; AG=11.2±3.6; GG=9.2±3.9), weaning body length (WBL; AA=46.8±2.4; AG=46.3±6.0; GG=43.8±5.3) and weaning chest circumference (WCC; AA=50.9±4.0; AG=50.7±4.6; GG=47.1±7.3) compare to AA and AG genotype (p<0.05). Individual with CC and CT genotypes at SNP g.1079C/T had higher (P<0.05) in WW (CC=12.6±2.1; CT=12.5±2.5) and average daily gain (ADG; CC=81.2±21.8; CT=79.3±26.2) than TT genotype (WW=10.6±3.1; ADG=58.3±30.5). This results suggested that SNP g.998A/G and g.1079C/T of MC4R gene could be used as the genetic marker of growth traits for selection in Bligon goat.

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“…Another study, performed by Zeng et al . (), indicated that a missense substitution in MC4R (identified as 420A>C; p.Asp101Thr) was associated with body weight in Beagle dogs 12–13 months of age. Recently, it was suggested that a missense polymorphism of the GPR120 gene (c.595C>A, p.Pro199Thr) may be associated with canine obesity, given that allele frequency differed significantly when dogs with a body condition score (BCS) of 3 were compared with those with a BCS of 4 and 5 (Miyabe et al .…”

Section: Polymorphisms Identified In Tnf Il6 and Retn Genesmentioning

confidence: 99%

Sequence analysis of three canine adipokine genes revealed an association between TNF polymorphisms and obesity in Labrador dogs

et al. 2015

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Obesity is an emerging health problem in purebred dogs. Due to their crucial role in energy homeostasis control, genes encoding adipokines are considered candidate genes, and their variants may be associated with predisposition to obesity. Searching for polymorphism was carried out in three adipokine genes (TNF, RETN and IL6). The study was performed on 260 dogs, including lean (n = 109), overweight (n = 88) and obese (n = 63) dogs. The largest cohort was represented by Labrador Retrievers (n = 136). Altogether, 24 novel polymorphisms were identified: 12 in TNF (including one missense SNP), eight in RETN (including one missense SNP) and four in IL6. Distributions of five common SNPs (two in TNF, two in RETN and one in IL6) were further analyzed with regard to body condition score. Two SNPs in the non-coding parts of TNF (c.-40A>C and c.233+14G>A) were associated with obesity in Labrador dogs. The obtained results showed that the studied adipokine genes are highly polymorphic and two polymorphisms in the TNF gene may be considered as markers predisposing Labrador dogs to obesity.

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The SNPs of Melanocortin 4 Receptor (<i>MC4R</i>) Associated with Body Weight in Beagle Dogs

Cited by 22 publications

References 19 publications

Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes

Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes

Association of Melanocortin 4 Receptor gene polymorphism with growth traits in Bligon goat

Sequence analysis of three canine adipokine genes revealed an association between TNF polymorphisms and obesity in Labrador dogs

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