The SNPs C.513A&gt;T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens

Zhang, Ze-tang; Gan, J K; Zhang, Wen-wu; Zhang, Dexiang; Zhang, Xiquan; Luo, Qianyi

doi:10.1016/s2095-3119(15)61313-2

Cited by 1 publication

(1 citation statement)

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“…Pang et al [23] analyzed the correlation between the SNPs in the IL-6 gene promoter region and the severity of enterovirus EV71 infection, indicating that IL-6 has a potential correlation with severe infection of human EV71. Zhang et al [24] reported that SNPs in the MHC B-F and SPOCK1 genes are significantly associated with resistance to Salmonella pullorum . In this study, we analyzed the association between SNPs of the IL-6 gene in the regulation region and coccidium resistance indexes and found that nine SNPs were significantly associated with E. tenella resistance.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Single Nucleotide Polymorphisms in the 5′ Regulatory Region of the IL-6 Gene with Eimeria tenella Resistance in Jinghai Yellow Chickens

Zou

Xin

et al. 2019

Genes

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Interleukin 6 (IL-6) is an immunoregulatory cytokine involved in various inflammatory and immune responses. To investigate the effects of single nucleotide polymorphisms (SNPs) and haplotypes of IL-6 on resistance to Eimeria tenella (E. tenella), SNPs in the 5′ regulatory region of IL-6 were detected with direct sequencing, and the effects of SNPs and haplotypes on resistance to E. tenella were analyzed by the least square model in Jinghai yellow chickens. Nineteen SNPs were identified in the 5′ regulation region of IL-6, among which three SNPs were newly discovered. The SNP association analysis results showed that nine of the SNPs were significantly associated with E. tenella resistance indexes; the A-483G locus was significantly associated with the GSH-Px, IL-2, and IL-17 indexes (p < 0.05); the C-447G locus was significantly associated with the SOD, GSH-Px, IL-17, and IL-2 indexes (p < 0.05); and the G-357A locus had significant effects on the CAT and IL-16 indexes (p < 0.05). Haplotype analysis showed that H2H3 and H2H5 were favorable haplotype combinations with good coccidium resistance. Furthermore, we used qRT-PCR and observed that the expression of IL-6 in the infection group was higher than that in the control group in the liver, proventriculus, small intestine, thymus, kidney, and bursa of Fabricius and extremely significantly different than that in the cecum especially (p < 0.01). In summary, SNPs and haplotypes in the 5′ regulatory region of IL-6 have important effects on E. tenella resistance, and the results will provide a reference for molecular marker selection of E. tenella resistance in Jinghai yellow chickens.

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Section: Discussionmentioning

confidence: 99%