The SNP rs516946 Interacted in the Association of MetS with Dietary Iron among Chinese Males but Not Females

Abstract

This study aimed to explore the role of the single nucleotide polymorphism (SNP) rs516946 of the Ankyrin 1 (ANK1) gene in the relationship between dietary iron and metabolic syndrome (MetS) in the Chinese population. A total of 2766 Chinese adults (1284 males and 1482 females) were recruited. A 3-day 24-h dietary recall and weighing of household condiments were used to assess dietary intake. Anthropometric and laboratory measurements were obtained. After adjusting for age, region, years of education, intentional physical exercise, physical activity level, smoking, alcohol use and energy intake, dietary iron and the SNP rs516946 were both correlated with MetS risk and interacted among the male participants. The trend between dietary iron and MetS risk remained among T allele non-carriers of males but not among T allele carriers of males. Both the SNP rs516946 and the ferritin level correlated positively with the aspartate aminotransferase (AST) level. ANK1 SNP rs516946 interacted in the association of MetS with dietary iron among Chinese males while no association was found among females. Periodic blood loss might prevent females from these associations. The SNP rs516946 might correlate with liver function.

Genetic variations in ACE2 gene associated with metabolic syndrome in southern China: a case–control study

“…A study on the relationship between ACE2 variants and left ventricular hypertrophy revealed that the minor alleles of ACE2 , rs2074192, and rs2106809, increased susceptibility to left ventricular hypertrophy in women, but not in men 21 . Another study explored the role of ANK1 SNP rs516946 in the relationship between dietary iron level and MetS, finding an interaction with the association between MetS and dietary iron in Chinese males, but not in females 22 . One possible reason for the sex-specific difference in our results is that ACE2 is located on the X chromosome, so the number of alleles varies significantly between sexes.…”

The Association between Dietary Iron Intake, SNP of the MTNR1B rs10830963, and Glucose Metabolism in Chinese Population

“…This study was based on the Shanghai Diet and Health Survey (SDHS), which was conducted from 2012 to 2013; the participants were followed up in 2019. It was a crosssectional study, and the methodology of this study has been described previously [17]. Briefly, a multi-stage stratified cluster random sampling was used to select participants from 54 communities across Shanghai from 2012 to 2013 (Figure 1).…”