The SNP polymorphisms associated with WSSV-resistance of prophenoloxidase in red swamp crayfish (Procambarus clarkii) and its immune response against white spot syndrome virus (WSSV)

Zhang, Long; Li, Yanhe; Wu, Minxian; Ouyang, Haofeng; Shi, Ruixue

doi:10.1016/j.aquaculture.2020.735787

Cited by 11 publications

(4 citation statements)

References 46 publications

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“…Recent study confirmed that the proPO played important role in crayfish immune function against WSSV (Zhang et al, 2021). RNA interference has previously been used to show that TGase and CP (haemolymph clotting mechanism) play critical roles in kuruma shrimp defence against WSSV (Maningas et al, 2008).…”

Section: Discussionmentioning

confidence: 87%

Natural ingredient paeoniflorin could be a lead compound against white spot syndrome virus infection in Litopenaeus vannamei

Liu

Shan

et al. 2021

Journal of Fish Diseases

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Section: Discussionmentioning

confidence: 87%

Natural ingredient paeoniflorin could be a lead compound against white spot syndrome virus infection in Litopenaeus vannamei

Liu

Shan

et al. 2021

Journal of Fish Diseases

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“…AMPs can bind with the components of the viral surface, subsequently resulting in the WSSV inactivation (Li et al, 2018). Recent study confirmed that the proPO played important role in crayfish immune function against WSSV (Zhang et al, 2021). RNA interference has previously been used to show that TGase and CP (haemolymph clotting mechanism) play critical roles in kuruma shrimp defence against WSSV (Maningas et al, 2008).…”

Section: Discussionmentioning

confidence: 98%

Antiviral activity of esculin against white spot syndrome virus: A new starting point for prevention and control of white spot disease outbreaks in shrimp seedling culture

Shan

Zhang

et al. 2021

Journal of Fish Diseases

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White spot syndrome virus (WSSV) is a pathogenic and threatening virus in shrimp culture for which there is no effective control strategy. Finding antiviral lead compounds for the development of anti-WSSV drugs is urgent and necessary; in this study, esculin from 12 monomeric compounds exhibited an excellent anti-WSSV activity. The results showed that esculin increased the survival rate of WSSV-infected shrimps by 59% and reduced the virus copy number in vivo over 90% at 100 μM. In the pre-treatment and post-treatment experiments, esculin could prevent and treat WSSV infection. Compared with the control group, the virus copy number decreased by 30% after 6 h of esculin pre-incubation with WSSV particles and inhibited horizontal transmission of WSSV to a certain extent. Considering that the antiviral activity of esculin was stable in the aquacultural water for 2 days, we evaluated the dosing pattern of continuous medication changes. Obviously, the survival rate of WSSVinfected shrimps was 0% at 108 h when no esculin exchange was made, while at 120 h the survival rate was over 40% at continuous medicine changes. In addition, esculin significantly increased the expression of antimicrobial peptides and thus improved the ability of shrimp to resist WSSV. Overall, our findings suggest that esculin has the potential to be developed into an anti-WSSV medicine.

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“…The proPO system, involved in the production of superoxides and hydroxyl radicals to kill the invading pathogen, is important in immune defense against WSSV infection 27 . For example, in red swamp crayfish Procambarus clarkia , injection with the recombinant proPO2 could significantly decrease 65% mortality of WSSV-infected crayfish and reduced the amount of WSSV copy number in hepatopancreas and gill 28 . In addition, the silencing of the proPO gene in freshwater prawn Macrobrachium rosenbergi makes them susceptible to WSSV 29 .…”

Section: Discussionmentioning

confidence: 99%

Effects of PmDOME and PmSTAT knockdown on white spot syndrome virus infection in Penaeus monodon

Laohawutthichai

Jatuyosporn

Supungul

et al. 2023

Sci Rep

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Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway plays an important role in antiviral immunity. This research reports the full-length DOME receptor gene in Penaeus monodon (PmDOME) and examines the effects of PmDOME and PmSTAT silencing on immune-related gene expressions in shrimp hemocytes during white spot syndrome virus (WSSV) infection. PmDOME and PmSTAT were up-regulated in shrimp hemocytes upon WSSV infection. Suppression of PmDOME and PmSTAT showed significant impacts on the expression levels of ProPO2 (melanization), Vago5 (interferon-like protein) and several antimicrobial peptides, including ALFPm3, Penaeidin3, CrustinPm1 and CrustinPm7. Silencing of PmDOME and PmSTAT reduced WSSV copy numbers and delayed the cumulative mortality caused by WSSV. We postulated that suppression of the JAK/STAT signaling pathway may activate the proPO, IFN-like antiviral cytokine and AMP production, resulting in a delay of WSSV-related mortality.

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The SNP polymorphisms associated with WSSV-resistance of prophenoloxidase in red swamp crayfish (Procambarus clarkii) and its immune response against white spot syndrome virus (WSSV)

Cited by 11 publications

References 46 publications

Natural ingredient paeoniflorin could be a lead compound against white spot syndrome virus infection in Litopenaeus vannamei

Natural ingredient paeoniflorin could be a lead compound against white spot syndrome virus infection in Litopenaeus vannamei

Antiviral activity of esculin against white spot syndrome virus: A new starting point for prevention and control of white spot disease outbreaks in shrimp seedling culture

Effects of PmDOME and PmSTAT knockdown on white spot syndrome virus infection in Penaeus monodon

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