The SNM Practice Guideline for Somatostatin Receptor Scintigraphy 2.0

Balon, Helena; Brown, Tracy L.; Goldsmith, Stanley J.; Silberstein, Edward B.; Krenning, Eric P.; Lang, Otto; Dillehay, Gary; Tarrance, Jennifer C.N.M.T.; Johnson, Matt C.N.M.T.; Stabin, Michael G.

doi:10.2967/jnmt.111.098277

Cited by 93 publications

(51 citation statements)

References 29 publications

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“…The reported radiation dosimetry results for the spleen using In-111 pentetreotide are 0.57 mGy/MBq (2.1 rad/mCi) in adults, 0.79 mGy/MBq (2.9 rad/mCi) in 15 year old children, and 1.8 mGy/MBq (6.7 rad/mCi) in 5 year old children [27]. Splenic radiation dose in Ga-68 DOTANOC PET studies (without including CT) is 0.0725 mGy/MBq (0.269 rad/mCi) [28].…”

Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

“…Treatment with cold SST analogs usually reduces splenic uptake of radiotracers for SSTR imaging [27,[37][38][39]. Several studies showed that treatment with cold SST analogs reduced the uptake in the spleen as well as in liver and kidneys, but it did not affect or even increased the uptake in the tumor [37][38][39].…”

Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

“…PET study is also quicker and easier to perform. Radiation dose to spleen also appears to be lower with Ga-68 DOTANOC PET imaging (without including CT) than with Tc-99m heat damaged RBC scintigraphy [27,28]. However, the main limitations of PET imaging of spleen with Ga-68 DOTA peptides are the high cost and limited availability of this radiotracer.…”

Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

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Significance of splenic uptake on somatostatin receptor imaging studies

Sarıkaya¹,

Sarıkaya²,

Alnafisi³

et al. 2018

Nucl. Med. Rev.

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Spleen shows a high physiological uptake on radionuclide somatostatin receptor (SSTR) imaging studies. Autoradiography and immunohistochemistry studies showed that SSTRs are mainly located in the red pulp of the spleen. In this review article we will summarize the significance of splenic uptake in SSTR imaging studies and will also present high resolution splenic images of Ga-68 DOTANOC PET in which splenic distribution of the radiotracer appears to be correlating with the distribution of red pulp.

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Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

Section: Splenic Uptake On Sstr Imaging Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Significance of splenic uptake on somatostatin receptor imaging studies

Sarıkaya¹,

Sarıkaya²,

Alnafisi³

et al. 2018

Nucl. Med. Rev.

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“…This key feature of NETs may be visualized using radiolabeled somatostatin receptor ligands and SPECT or PET. Still, 111 In-diethylenetriaminepentaacetic acid (DTPA)-octreotide is considered the standard method according to current international guidelines (4,5). However, because of the better sensitivity, spatial resolution, and inherently quantitative nature of PET, somatostatin receptor imaging (SRI) with PET is increasingly used.…”

mentioning

confidence: 99%

⁶⁴Cu-DOTATATE PET for Neuroendocrine Tumors: A Prospective Head-to-Head Comparison with ¹¹¹In-DTPA-Octreotide in 112 Patients

et al. 2015

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Neuroendocrine tumors (NETs) can be visualized using radiolabeled somatostatin analogs. We have previously shown the clinical potential of 64 Cu-DOTATATE in a small first-in-human feasibility study. The aim of the present study was, in a larger prospective design, to compare on a head-to-head basis the performance of 64 In-diethylenetriaminepentaacetic acid (DTPA)-octreotide ( 111 In-DTPA-OC) as a basis for implementing 64 Cu-DOTATATE as a routine. Methods: We prospectively enrolled 112 patients with pathologically confirmed NETs of gastroenteropancreatic or pulmonary origin. All patients underwent both PET/CT with 64 Cu-DOTATATE and SPECT/CT with 111 In-DTPA-OC within 60 d. PET scans were acquired 1 h after injection of 202 MBq (range, 183-232 MBq) of 64 Cu-DOTATATE after a diagnostic contrast-enhanced CT scan. Patients were followed for 42-60 mo for evaluation of discrepant imaging findings. The McNemar test was used to compare the diagnostic performance. Results: Eightyseven patients were congruently PET-and SPECT-positive. No SPECT-positive cases were PET-negative, whereas 10 false-negative SPECT cases were identified using PET. The diagnostic sensitivity and accuracy of 64 Cu-DOTATATE (97% for both) were significantly better than those of 111 In-DTPA-OC (87% and 88%, respectively, P 5 0.017). In 84 patients (75%), 64 Cu-DOTATATE identified more lesions than 111 In-DTPA-OC and always at least as many. In total, twice as many lesions were detected with 64 Cu-DOTATATE than with 111 In-DTPA-OC. Moreover, in 40 of 112 cases (36%) lesions were detected by 64 Cu-DOTATATE in organs not identified as disease-involved by 111 In-DTPA-OC. Conclusion: With these results, we demonstrate that 64 Cu-DOTATATE is far superior to 111 In-DTPA-OC in diagnostic performance in NET patients. Therefore, we do not hesitate to recommend implementation of 64 Cu-DOTATATE as a replacement for 111 In-DTPA-OC.

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“…Mosaic perfusion is also a very commonly reported CT finding in DIPNECH that results from vasoconstriction in the areas of small airway obstruction [3]. Somatostatin receptor scintigraphy, also known as octreotide scan, is a very valuable investigation for detection and staging of neuroendocrine tumors [5]. It is based on the principle that neuroendocrine tumors have an over-expression of somatostatin receptors.…”

Section: Discussionmentioning

confidence: 99%

A Case of DIPNECH Presenting as Usual Interstitial Pneumonia

Chatterjee

Kamimoto

Dunn

et al. 2016

Advances in Respiratory Medicine

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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disease that is classically described as presenting with cough, dyspnea, and wheezing in non-smoker middle aged females. Pulmonary function tests commonly demonstrate an obstructive pattern and CT of chest usually reveals diffuse air trapping with mosaic pattern. We present a case of patient with DIPNECH manifesting with restrictive pattern and as usual interstitial pneumonia on imaging.

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The SNM Practice Guideline for Somatostatin Receptor Scintigraphy 2.0

Cited by 93 publications

References 29 publications

Significance of splenic uptake on somatostatin receptor imaging studies

Significance of splenic uptake on somatostatin receptor imaging studies

⁶⁴Cu-DOTATATE PET for Neuroendocrine Tumors: A Prospective Head-to-Head Comparison with ¹¹¹In-DTPA-Octreotide in 112 Patients

A Case of DIPNECH Presenting as Usual Interstitial Pneumonia

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The SNM Practice Guideline for Somatostatin Receptor Scintigraphy 2.0

Cited by 93 publications

References 29 publications

Significance of splenic uptake on somatostatin receptor imaging studies

Significance of splenic uptake on somatostatin receptor imaging studies

64Cu-DOTATATE PET for Neuroendocrine Tumors: A Prospective Head-to-Head Comparison with 111In-DTPA-Octreotide in 112 Patients

A Case of DIPNECH Presenting as Usual Interstitial Pneumonia

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⁶⁴Cu-DOTATATE PET for Neuroendocrine Tumors: A Prospective Head-to-Head Comparison with ¹¹¹In-DTPA-Octreotide in 112 Patients