The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation

Wang, Hong‐Hui; Dong, Jingjing; Li, Gaozhi; Tan, Yingjun; Zhao, Hai; Zhang, Lijun; Wang, Yixuan; Hu, Zebing; Cao, Xinsheng; Shi, Fei; Zhang, Shu

doi:10.1016/j.bbrc.2021.03.133

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Reactive oxygen species (ROS) inhibit the function of osteoblasts ( Manolagas, 2010 ; Steller et al, 2018 ), promote MC3T3-E1 cell apoptosis, and downregulate the expression of MAF BZIP transcription factor G (MafG) ( Wang et al, 2021b ). Therefore, increased ROS expression in microgravity is also one of the key factors for bone loss.…”

Section: Mechanical Stimulation With Osteoblastsmentioning

confidence: 99%

Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

Liu

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and osteogenic activities. The remodeling of bone tissue is a continuous ongoing process. Osteoclasts mainly play a role in bone resorption, whereas osteoblasts are mainly involved in bone remodeling processes, such as bone cell formation, mineralization, and secretion. These cell types balance and restrict each other to maintain bone tissue metabolism. Bone tissue is very sensitive to mechanical stress stimulation. Unloading and loading of mechanical stress are closely related to the differentiation and formation of osteoclasts and bone resorption function as well as the differentiation and formation of osteoblasts and bone formation function. Consequently, mechanical stress exerts an important influence on the bone microenvironment and bone metabolism. This review focuses on the effects of different forms of mechanical stress stimulation (including gravity, continuously compressive pressure, tensile strain, and fluid shear stress) on osteoclast and osteoblast function and expression mechanism. This article highlights the involvement of osteoclasts and osteoblasts in activating different mechanical transduction pathways and reports changings in their differentiation, formation, and functional mechanism induced by the application of different types of mechanical stress to bone tissue. This review could provide new ideas for further microscopic studies of bone health, disease, and tissue damage reconstruction.

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Section: Mechanical Stimulation With Osteoblastsmentioning

confidence: 99%

Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

Liu

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…However, in addition to cancer cells, some normal cells that divide vigorously, such as stem cells, basal skin cells, and gastrointestinal mucosa cells, are also targeted by ionizing radiation. Unrepaired DNA damage often induces apoptosis and cell cycle arrest [ 14 , 15 ]. Cell apoptosis owing to radiation can be mediated by either p53 or the sphingomyelin/ceramide pathways [ 16 , 17 ].…”

Section: The Basic Biological Mechanism By Which Radiotherapy Causes ...mentioning

confidence: 99%

The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction

Tang

Liang

et al. 2022

Stem Cell Res Ther

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Background Postmastectomy radiotherapy is considered to be a necessary treatment in the therapy of breast cancer, while it will cause soft tissue damage and complications, which are closely related to the success rate and effectiveness of breast reconstruction. After radiotherapy, cutaneous tissue becomes thin and brittle, and its compliance decreases. Component fat grafting and adipose-derived stem cell therapy are considered to have great potential in treating radiation damage and improving skin compliance after radiotherapy. Main body In this paper, the basic types and pathological mechanisms of skin and soft tissue damage to breast skin caused by radiation therapy are described. The 2015–2021 studies related to stem cell therapy in PubMed were also reviewed. Studies suggest that adipose-derived stem cells exert their biological effects mainly through cargoes carried in extracellular vesicles and soluble secreted factors. Compared to traditional fat graft breast reconstruction, ADSC therapy amplifies the effects of stem cells in it. In order to obtain a more purposeful therapeutic effect, proper stem cell pretreatment may achieve more ideal and safe results. Conclusion Recent research works about ADSCs and other MSCs mainly focus on curative effects in the acute phase of radiation injury, and there is little research about treatment of chronic phase complications. The efficacy of stem cell therapy on alleviating skin fibrosis and its underlying mechanism require further research.

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Advances in China Space Medical Experiment Research

CHEN¹,

Liu²,

WANG³

et al. 2022

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The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation

Cited by 3 publications

References 25 publications

Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction

Advances in China Space Medical Experiment Research

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