The small intestinal basic electrical rhythm (slow wave) frequency gradient in normal men and in patients with a variety of diseases

Christensen, James; Schedl, Harold P.; Clifton, James

doi:10.1016/s0016-5085(66)80069-0

Cited by 120 publications

(49 citation statements)

References 10 publications

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“…The amplitude and frequency of the pacesetter potential is entirely compatible with previous studies (Daniel, Carlow, Wachter, Sutherland, and Bogoch, 1958;Christensen, Schedl, and Clifton, 1966). The overall 30% spontaneous motility in the fasted state in the 25 patients studied is much lower than previously reported (Cummins, 1954;Code, Rogers, Schlegel, Hightower, and Bargen, 1957;Daniel et al, 1958) and this may be due to the non-obstructing effect of the open-tip catheter technique which enables resting activity to be recorded.…”

Section: Discussionsupporting

confidence: 89%

The effects of humoral agents on the myoelectrical activity of the terminal ileum

Waterfall¹,

Brown²,

Duthie³

et al. 1972

Gut

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SUMMARY Electrical and motor activities of the terminal ileum have been recorded in 25 patients with a permanent ileostomy. Records made within a week of formation of the ileostomy show an increased motor activity which is significantly reduced after four weeks. Intravenous infusion of gastrin, 1 ,ug/kg-hr, was accompanied by a significant increase in action potentials and in the percentage motility. Conversely, secretin 1 unit/kg-hr was associated with a decrease in action potentials and in percentage motor activity.

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Section: Discussionsupporting

confidence: 89%

The effects of humoral agents on the myoelectrical activity of the terminal ileum

Waterfall¹,

Brown²,

Duthie³

et al. 1972

Gut

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“…Ultrastructurally, the ICC of the human stomach have typical features (50) and have close contact with smooth muscle cells and nerve varicosities (17) very similar to the rat and mouse (26,43). The electrical pacemaker activities in both human (16) and mouse (6,14) stomach and human (9) and mouse (36) small intestine are not fully elucidated but at this point do not appear to be fundamentally different. Hence, the rat and mouse appear to be suitable models to gain insight into human gastroduodenal motility (43).…”

Section: Discussionmentioning

confidence: 99%

Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine

Wang

Lammers²,

Berčík³

et al. 2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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The frequency and propagation velocity of distension-induced peristaltic contractions in the antrum and duodenum are distinctly different and depend on activation of intrinsic excitatory motoneurons as well as pacemaker cells, the interstitial cells of Cajal associated with Auerbach's plexus (ICC-AP). Because ICC are critical for coordination of motor activities along the long axis of many regions in the gut, the role of ICC in antroduodenal coordination was investigated. We used immunohistochemistry, electron microscopy, simultaneous multiple electrical recordings in vitro, and videofluoroscopy in vivo in mice and rats. A strongly reduced number of ICC-AP with loss of network characteristics was observed in a 4-mm area in the rat and a 1-mm area in the mouse pyloric region. The pyloric region showed a slow wave-free gap of 4.1 mm in rats and 1.3 mm in mice. Between antrum and duodenum, there was no interaction of electrical activities and in the absence of gastric emptying, there was no coordination of motor activities. When the pyloric sphincter opened, 2.4 s before the front of the antral wave reached the pylorus, the duodenum distended after receiving gastric content and aboral duodenal peristalsis was initiated, often disrupting other motor patterns. The absence of ICC-AP and slow wave activity in the pyloric region allows the antrum and duodenum to have distinct uncoordinated motor activities. Coordination of aborally propagating peristaltic antral and duodenal activity is initiated by opening of the pylorus, which is followed by distention-induced duodenal peristalsis. Throughout this coordinated motor activity, the pacemaker systems in antrum and duodenum remain independent.

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“…Aborad to this point, there is a diminishing slow-wave frequency gradient along the small bowel to a rate of 14 cpm in the distal ileum [5,23]. In humans, slow waves in the duodenum and proximal jejunum occur at about 12 cpm with an aborad gradient to about 9 cpm in the terminal ileum [24,25]. Whether a proximal plateau of identical frequencies is present in the human duodenum and proximal jejunum has not been clearly shown [24].…”

Section: Small Intestinal Myoelectrical Activitymentioning

confidence: 99%

Mechanisms and Potential Applications of Intestinal Electrical Stimulation

Yin¹,

Chen²

2009

Dig Dis Sci

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It is concluded that intestinal electrical stimulation may have promising applications for treating motility disorders associated with altered intestinal contractile activity. The most recent studies have revealed possible applications of intestinal electrical stimulation for the treatment of obesity. Basic research results are promising; however, further clinical studies are needed to bring IES from bench to bedside.

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The small intestinal basic electrical rhythm (slow wave) frequency gradient in normal men and in patients with a variety of diseases

Cited by 120 publications

References 10 publications

The effects of humoral agents on the myoelectrical activity of the terminal ileum

The effects of humoral agents on the myoelectrical activity of the terminal ileum

Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine

Mechanisms and Potential Applications of Intestinal Electrical Stimulation

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